人类中的自发自体玫瑰花结形成细胞。是T淋巴细胞亚群的标志物吗？
Spontaneous autorosette-forming cells in man. A marker for a subset population of T lymphocytes?
作者信息
Gluckman J C, Montambault P
出版信息
Clin Exp Immunol. 1975 Nov;22(2):302-10.
Abstract
A subpopulation of human peripheral blood lymphocytes are capable of binding with human (autologous or allogeneic) erythrocytes, forming rosettes. The conditions which lead to autorosette formation are similar to those required for sheep red-cell rosetting. Ageing human erythrocytes are shown to bear less of the determinants involved in the phenomenon than younger ones. Evidence is presented that autorosetting is a T-cell marker. As autorosette-forming cells are very sensitive to the inhibiting effects of ATG they could therefore belong to a T-cell subpopulation.
摘要
人类外周血淋巴细胞的一个亚群能够与人类（自体或异体）红细胞结合，形成玫瑰花结。导致自身玫瑰花结形成的条件与绵羊红细胞玫瑰花结形成所需的条件相似。研究表明，衰老的人类红细胞比年轻红细胞携带的参与该现象的决定簇更少。有证据表明自身玫瑰花结形成是一种T细胞标记。由于自身玫瑰花结形成细胞对抗胸腺细胞球蛋白的抑制作用非常敏感，因此它们可能属于T细胞亚群。
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