Fournier C, Charreire J
Clin Exp Immunol. 1977 Sep;29(3):468-73.
Studies made of 115 normal subjects of both sexes aged 20--94 years showed that autologous rosette-forming cell levels in human peripheral blood lymphocytes were related to age and sex. However, no such relationship was found in response to phytohaemagglutinin performed in the same subjects. The nature of these autorosettes in human peripheral blood lymphocytes was studied. A significant decrease in autorosette levels was observed after passage through nylon wool at high RBC/WC ratios, and at any ratio after E-rosette depletion. The results suggesting a T-cell origin of autorosettes were confirmed by the existence of mixed autologous erythrocyte and sheep red blood cell rosettes.
对115名年龄在20至94岁之间的正常男女受试者进行的研究表明，人类外周血淋巴细胞中的自体花环形成细胞水平与年龄和性别有关。然而，在对同一受试者进行的植物血凝素反应中未发现这种关系。对人类外周血淋巴细胞中这些自体花环的性质进行了研究。在高红细胞/白细胞比例下通过尼龙毛后，以及在E花环耗竭后的任何比例下，均观察到自体花环水平显著下降。自体红细胞和绵羊红细胞混合花环的存在证实了提示自体花环起源于T细胞的结果。
