• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一些常见可变型免疫球蛋白缺乏血症患者中存在IgG重链糖基化失败的情况。

Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia.

作者信息

Ciccimarra F, Rosen F S, Schneeberger E, Merler E

出版信息

J Clin Invest. 1976 May;57(5):1386-90. doi: 10.1172/JCI108407.

DOI:10.1172/JCI108407
PMID:1083397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC436792/
Abstract

Four patients with common, variable agammaglobulinemia were preveiously reported to have normal numbers of circulating B lymphocytes which synthesized normal amounts of IgG in tissue culture but failed to secrete the newly synthesized IgG. The B lymphocytes of these patients fail to incorporate [3H]mannose and/or [3H]glucosamine into newly synthesized IgG, whereas such incorporation appears to occur just before IgG secretion in cultures of normal B lymphocytes.

摘要

先前报道，4例普通变异型无丙种球蛋白血症患者循环B淋巴细胞数量正常，这些细胞在组织培养中合成正常量的IgG，但无法分泌新合成的IgG。这些患者的B淋巴细胞不能将[3H]甘露糖和/或[3H]氨基葡萄糖掺入新合成的IgG中，而在正常B淋巴细胞培养物中，这种掺入似乎恰好在IgG分泌之前发生。

相似文献

1
Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia.一些常见可变型免疫球蛋白缺乏血症患者中存在IgG重链糖基化失败的情况。
J Clin Invest. 1976 May;57(5):1386-90. doi: 10.1172/JCI108407.
2
Lymphoid cell lines from patients with "non-secretory" agammaglobulinemia produce glycosylated heavy chains which are reduced in molecular weight.来自“非分泌型”无丙种球蛋白血症患者的淋巴细胞系产生分子量降低的糖基化重链。
J Mol Cell Immunol. 1984;1(5):279-91.
3
Biosynthesis and secretion of immunoglobulins by peripheral blood lymphocytes in severe hypogammaglobulinemia and by cultured lymphoblast cells.严重低丙种球蛋白血症患者外周血淋巴细胞及培养的淋巴母细胞产生和分泌免疫球蛋白的情况
Birth Defects Orig Artic Ser. 1975;11(1):81-6.
4
Glucocorticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes. III. Common variable immunodeficiency.糖皮质激素对商陆丝裂原刺激的人淋巴细胞免疫球蛋白合成的增强作用。III. 普通可变免疫缺陷
Clin Exp Immunol. 1981 Aug;45(2):399-408.
5
The role of suppressor cells in the pathogenesis of common variable hypogammaglobulinemia and the immunodeficiency associated with myeloma.抑制细胞在常见变异型低丙种球蛋白血症发病机制及与骨髓瘤相关免疫缺陷中的作用。
Fed Proc. 1976 Jul;35(9):2067-72.
6
Differentiation capacity of cultured B lymphocytes from immunodeficient patients.免疫缺陷患者培养的B淋巴细胞的分化能力。
J Clin Invest. 1973 Dec;52(12):3180-9. doi: 10.1172/JCI107518.
7
Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: low immunoglobulin production on stimulation of normal B cells.常见可变型低丙种球蛋白血症患者血液中具有树突状形态的低密度细胞缺陷：正常B细胞受刺激后免疫球蛋白产生减少。
Clin Exp Immunol. 1985 Jul;61(1):189-94.
8
Interleukin-4 suppresses immunoglobulin production by peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) induced by supernatants of T cell clones.白细胞介素-4抑制由T细胞克隆上清液诱导的常见变异型免疫缺陷（CVI）患者外周血淋巴细胞产生免疫球蛋白。
Clin Exp Immunol. 1989 Dec;78(3):341-7.
9
Comparative study of bone marrow and blood B cells in infantile and acquired agammaglobulinemia. Possible role of circulating anti-IgM in pathogenesis.婴儿期和获得性无丙种球蛋白血症中骨髓和血液B细胞的比较研究。循环抗IgM在发病机制中的可能作用。
J Clin Invest. 1973 Sep;52(9):2218-24. doi: 10.1172/JCI107407.
10
The influence of recombinant mediators on in vitro IgG subclass secretion by peripheral blood mononuclear cells from patients with hypogammaglobulinemia and from normal donors.重组介质对低丙种球蛋白血症患者及正常供体外周血单个核细胞体外IgG亚类分泌的影响。
Eur Cytokine Netw. 1993 Jul-Aug;4(4):299-306.

引用本文的文献

1
The role and potential mechanism of immunoglobulin G N-glycosylation in gastrointestinal tumors.免疫球蛋白G N-糖基化在胃肠道肿瘤中的作用及潜在机制
Med Mol Morphol. 2025 Aug 25. doi: 10.1007/s00795-025-00448-w.
2
Immunoglobulin G Glycosylation in Diseases.免疫球蛋白 G 糖基化在疾病中的作用。
Exp Suppl. 2021;112:395-431. doi: 10.1007/978-3-030-76912-3_13.
3
The history of IgG glycosylation and where we are now.IgG 糖基化的历史和现状。
Glycobiology. 2020 Mar 20;30(4):202-213. doi: 10.1093/glycob/cwz065.
4
Lymphocyte subpopulations in primary immunodeficiency disorders.原发性免疫缺陷病中的淋巴细胞亚群
Indian J Pediatr. 1982 May-Jun;49(398):399-408. doi: 10.1007/BF02834434.
5
Isotypes of surface immunoglobulin on B lymphocytes from patients with immune deficiency.免疫缺陷患者B淋巴细胞表面免疫球蛋白的同种型。
J Clin Immunol. 1982 Jan;2(1):30-4. doi: 10.1007/BF00915975.
6
Glucocorticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes. III. Common variable immunodeficiency.糖皮质激素对商陆丝裂原刺激的人淋巴细胞免疫球蛋白合成的增强作用。III. 普通可变免疫缺陷
Clin Exp Immunol. 1981 Aug;45(2):399-408.
7
In vitro regulation of IgA subclass synthesis. I. Discordance between plasma cell production and antibody secretion.体外对IgA亚类合成的调节。I. 浆细胞产生与抗体分泌之间的不一致。
J Exp Med. 1982 Dec 1;156(6):1615-21. doi: 10.1084/jem.156.6.1615.
8
Polyclonal immunoglobulin secretion in patients with common variable immunodeficiency using monoclonal B cell differentiation factors.使用单克隆B细胞分化因子治疗常见可变免疫缺陷患者的多克隆免疫球蛋白分泌
J Clin Invest. 1984 Dec;74(6):2115-20. doi: 10.1172/JCI111636.
9
Epstein-Barr virus-induced immunoglobulin synthesis by B cells from individuals with late-onset panhypogammaglobulinemia.爱泼斯坦-巴尔病毒诱导迟发性全丙种球蛋白血症患者B细胞合成免疫球蛋白
J Clin Immunol. 1983 Jul;3(3):253-9. doi: 10.1007/BF00915349.
10
Autologous mixed lymphocyte reaction in man. IV. Decreased autologous mixed lymphocyte culture response in patients with common variable immunodeficiency.
J Clin Immunol. 1983 Jan;3(1):78-83. doi: 10.1007/BF00919142.

本文引用的文献

1
ISOLATION AND STUDY OF THE FUNCTION OF HUMAN GAMMA-2-GLOBULIN GLYCOPEPTIDE.
Immunochemistry. 1965 Mar;47:61-6.
2
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
3
Immunoglobulin synthesis and secretion. II. Radioautographic studies of sites of addition of carbohydrate moieties and intracellular transport.免疫球蛋白的合成与分泌。II. 碳水化合物部分添加位点及细胞内运输的放射自显影研究。
J Cell Biol. 1970 Jul;46(1):52-63. doi: 10.1083/jcb.46.1.52.
4
Clinical, serologic and leukocyte function studies on patients with idiopathic "acquired" agammaglobulinemia and their families.对特发性“获得性”无丙种球蛋白血症患者及其家族进行的临床、血清学和白细胞功能研究。
Am J Med. 1970 Jan;48(1):48-53. doi: 10.1016/0002-9343(70)90097-5.
5
The covalent structure of an entire gammaG immunoglobulin molecule.完整的γG免疫球蛋白分子的共价结构。
Proc Natl Acad Sci U S A. 1969 May;63(1):78-85. doi: 10.1073/pnas.63.1.78.
6
Identification and characterization of subpopulations of lymphocytes in human peripheral blood after fractionation on discontinuous gradients of albumin. The cellular defect in X-linked agammaglobulinemia.在白蛋白不连续梯度上进行分级分离后，人外周血中淋巴细胞亚群的鉴定与表征。X连锁无丙种球蛋白血症中的细胞缺陷。
J Clin Invest. 1973 Jul;52(7):1726-34. doi: 10.1172/JCI107354.
7
Human lymphocyte mitogenic factor: synthesis by sensitized thymus-derived lymphocytes, dependence of expression on the presence of antigen.人淋巴细胞促有丝分裂因子：由致敏胸腺来源淋巴细胞合成，表达对抗原存在的依赖性。
Cell Immunol. 1974 Jan;10(1):86-104. doi: 10.1016/0008-8749(74)90154-3.
8
Heterogeneity of "acquired" or common variable agammaglobulinemia.“获得性”或常见变异型无丙种球蛋白血症的异质性。
N Engl J Med. 1974 Jul 4;291(1):1-6. doi: 10.1056/NEJM197407042910101.
9
Two decades of research on the biosynthesis of saccharides.
Science. 1971 Jun 25;172(3990):1299-303. doi: 10.1126/science.172.3990.1299.
10
Biosynthesis of immunoglobulin A (IgA). Secretion and addition of carbohydrate to monomer and polymer forms of a mouse myeloma protein.免疫球蛋白A（IgA）的生物合成。小鼠骨髓瘤蛋白单体和多聚体形式的分泌及碳水化合物的添加。
Biochem J. 1973 Nov;136(3):589-96. doi: 10.1042/bj1360589.