一些常见可变型免疫球蛋白缺乏血症患者中存在IgG重链糖基化失败的情况。
Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia.
作者信息
Ciccimarra F, Rosen F S, Schneeberger E, Merler E
出版信息
J Clin Invest. 1976 May;57(5):1386-90. doi: 10.1172/JCI108407.
Abstract
Four patients with common, variable agammaglobulinemia were preveiously reported to have normal numbers of circulating B lymphocytes which synthesized normal amounts of IgG in tissue culture but failed to secrete the newly synthesized IgG. The B lymphocytes of these patients fail to incorporate [3H]mannose and/or [3H]glucosamine into newly synthesized IgG, whereas such incorporation appears to occur just before IgG secretion in cultures of normal B lymphocytes.
摘要
先前报道，4例普通变异型无丙种球蛋白血症患者循环B淋巴细胞数量正常，这些细胞在组织培养中合成正常量的IgG，但无法分泌新合成的IgG。这些患者的B淋巴细胞不能将[3H]甘露糖和/或[3H]氨基葡萄糖掺入新合成的IgG中，而在正常B淋巴细胞培养物中，这种掺入似乎恰好在IgG分泌之前发生。
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