Harrison H R, Alexander E R, Chiang W T, Giddens W E, Boyce J T, Benjamin D, Gale J L
J Infect Dis. 1979 Feb;139(2):141-6. doi: 10.1093/infdis/139.2.141.
Three infant male baboons were inoculated with a strain of CHLAMYDIA TRACHOMATIS ISOLATED FROM A HUMAN INFANT WITH PNEUMONITIS. One baboon, inoculated by intratracheal, nasopharyngeal, and oropharyngeal seeding, had rales, radiographic evidence of pneumonia, persistent nasopharyngeal C. trachomatis infection, and a four-fold rise in titer of antibody. At sacrifice 24 days after inoculation, nasopharynx, trachea, airways, and lung yielded C. trachomatis, and epithelial inclusions were seen by light and immunofluorescent microscopy. Histopathologic changes noted were nearly identical to those in a lung biopsy specimen from a human infant and pneumonitis and nasopharyngeal C. trachomatis. The second baboon was inoculated by tracheal seeding and maintained nasopharyngeal C. trachomatis until killed 30 days later. Autopsy revealed nasopharyngitis and patchy mild pneumonitis. The third baboon was inoculated by nasopharyngeal seeding and maintained nasopharyngeal C. trachomatis for 49 days. Both of the latter baboons seroconverted. Infant baboons appear to be useful animal models for C. trachomatis nasopharyngitis and pneumonia.
三只雄性幼狒狒接种了从一名患肺炎的人类婴儿分离出的沙眼衣原体菌株。其中一只狒狒通过气管内、鼻咽和口咽接种，出现啰音、肺炎的影像学证据、持续性鼻咽沙眼衣原体感染以及抗体滴度四倍升高。接种后24天处死时，在鼻咽、气管、气道和肺中检出沙眼衣原体，通过光学显微镜和免疫荧光显微镜观察到上皮内包涵体。观察到的组织病理学变化与人类婴儿肺活检标本中的变化几乎相同，伴有肺炎和鼻咽沙眼衣原体感染。第二只狒狒通过气管接种，在30天后处死前一直保持鼻咽沙眼衣原体感染。尸检显示有鼻咽炎和散在性轻度肺炎。第三只狒狒通过鼻咽接种，保持鼻咽沙眼衣原体感染49天。后两只狒狒均出现血清转化。幼狒狒似乎是沙眼衣原体鼻咽炎和肺炎的有用动物模型。
