Kuperman O J, Bach F H
J Exp Med. 1976 Jun 1;143(6):1545-50. doi: 10.1084/jem.143.6.1545.
The LD and SD antigens of the major histocompatibility complex subserve differential roles in the induction of the proliferative phase in mixed lymphocyte culture and in the cytotoxic reaction seen in cell-mediated lympholysis. The present study suggests that they also behave differently in the neonatal induction of tolerance. SD antigens appear to induce tolerance in the cytotoxic T lymphocytes very effectively, whereas LD antigens (or the cytotoxic targets coded by genes in the I and/or S regions) are relatively ineffective in this regard. LD antigens presented neonatally are effective at inducing tolerance in the proliferating helper cells.
主要组织相容性复合体的LD和SD抗原在混合淋巴细胞培养中增殖期的诱导以及细胞介导的淋巴细胞溶解中的细胞毒性反应中发挥不同作用。本研究表明，它们在新生儿耐受诱导中也表现不同。SD抗原似乎能非常有效地诱导细胞毒性T淋巴细胞产生耐受，而LD抗原（或I区和/或S区基因编码的细胞毒性靶标）在这方面相对无效。新生期呈现的LD抗原能有效地诱导增殖辅助细胞产生耐受。
