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天花中抗体的最低保护水平。

The minimum protective level of antibodies in smallpox.

作者信息

Sarkar J K, Mitra A C, Mukherjee M K

出版信息

Bull World Health Organ. 1975;52(3):307-11.

PMID:1084801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366379/
Abstract

Blood samples from 57 contacts of 6 smallpox cases were tested for haemagglutination-inhibiting (HI) and neutralizing antibodies. All 6 contacts who subsequently developed smallpox were unvaccinated and had neutralizing antibody titres of 10 or less. However, 6 unvaccinated contacts with similar antibody levels did not develop smallpox. None of the 41 vaccinated contacts, regardless of their antibody level, contracted the disease.

摘要

对6例天花病例的57名接触者的血样进行了血凝抑制(HI)和中和抗体检测。随后感染天花的所有6名接触者均未接种疫苗,且中和抗体滴度为10或更低。然而,6名抗体水平相似的未接种疫苗的接触者并未感染天花。41名接种疫苗的接触者,无论其抗体水平如何,均未感染该病。

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本文引用的文献

1
Virus and virus antigen in the blood of smallpox patients; their significance in early diagnosis and prognosis.天花患者血液中的病毒及病毒抗原;它们在早期诊断和预后中的意义。
Lancet. 1953 Jul 25;265(6778):164-6. doi: 10.1016/s0140-6736(53)90107-x.
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Antibody response in haemorrhagic smallpox.出血性天花中的抗体反应。
Indian J Med Res. 1967 Nov;55(11):1143-9.
3
A study of inapparent infection in smallpox.一项关于天花隐性感染的研究。
Am J Epidemiol. 1971 Sep;94(3):252-68. doi: 10.1093/oxfordjournals.aje.a121319.
4
Pattern of intrafamilial transmission of smallpox in Calcutta, India.印度加尔各答天花的家庭内传播模式。
Bull World Health Organ. 1974;51(3):219-25.
5
Virus excretion in smallpox. 2. Excretion in the throats of household contacts.天花中的病毒排泄。2. 家庭接触者咽喉中的排泄情况。
Bull World Health Organ. 1973 May;48(5):523-7.
6
Virus excretion in smallpox. 1. Excretion in the throat, urine, and conjunctiva of patients.天花病毒的排泄。1. 患者咽喉、尿液及结膜中的病毒排泄。
Bull World Health Organ. 1973 May;48(5):517-22.
7
[Collection of blood on filter paper disks for the purpose of serological studies].[为血清学研究目的在滤纸片上采集血液]
Microbiol Parazitol Epidemiol (Bucur). 1968 Sep-Oct;13(5):459-64.
8
Virulence of variola virus isolated from smallpox cases of varying severity.从不同严重程度天花病例中分离出的天花病毒的毒力。
Indian J Med Res. 1967 Jan;55(1):13-20.