系统性硬化症中细胞介导免疫缺陷与内脏疾病的关系。
The relationship of defective cell-mediated immunity to visceral disease in systemic sclerosis.
作者信息
Hughes P, Holt S, Rowell N R, Allonby I D, Janis K, Dodd J K
出版信息
Clin Exp Immunol. 1977 May;28(2):233-40.
Abstract
Phytohaemagglutinin-induced lymphocyte transformation and circulating thymus-dependent (T) lymphocyte numbers were studied in twenty-eight patients with systemic sclerosis (SS), in fifty normal controls and eleven elderly controls. Patients with SS were found to have impaired lymphocyte transformation responses which showed a positive correlation with both the number of circulating T lymphocytes and the extent of visceral involvement by the disease. This defect of cell-mediated immunity could not be attributed to the effects of increasing age, corticosteroid treatment, iron and folate deficiency or inhibitory serum factors and may have pathogenetic implications for the disorder.
摘要
对28例系统性硬化症（SS）患者、50名正常对照者和11名老年对照者研究了植物血凝素诱导的淋巴细胞转化及循环中胸腺依赖性（T）淋巴细胞数量。发现SS患者淋巴细胞转化反应受损，且与循环T淋巴细胞数量及疾病内脏受累程度均呈正相关。这种细胞介导免疫缺陷不能归因于年龄增长、皮质类固醇治疗、铁和叶酸缺乏或抑制性血清因子的影响，可能对该疾病具有发病机制方面的意义。
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