Hirsch C, Ploegh H L
Dept of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Trends Cell Biol. 2000 Jul;10(7):268-72. doi: 10.1016/s0962-8924(00)01768-2.
Proteasomes are soluble, but can also be found in association with subcellular organelles. Adaptors capable of mediating interactions between proteasomes and intracellular organelles have not yet been identified, although they might exist. Although most proteasomal substrates are soluble, some membrane-bound proteins are also degraded by the proteasome. Processing of such insoluble substrates might cause proteasomes to be organelle-bound by tethering the degradative apparatus to the organelle.
蛋白酶体是可溶性的，但也可与亚细胞器结合存在。尽管可能存在能够介导蛋白酶体与细胞内细胞器相互作用的衔接蛋白，但目前尚未被鉴定出来。虽然大多数蛋白酶体底物是可溶性的，但一些膜结合蛋白也可被蛋白酶体降解。处理这类不溶性底物可能会通过将降解装置拴系到细胞器上，使蛋白酶体与细胞器结合。
