Wallace R B, Landrigan P J, Smith E A, Pifer J, Teller B, Foster S O
Bull World Health Organ. 1976;53(4):361-4.
To evaluate the effectiveness of measles vaccine in reduced dosage, Schwarz live, further attenuated measles virus vaccine was given in various doses by jet injector to 967 seronegative children aged 7-30 months in rural villages in the Northwest State of Nigeria. For children over 12 months of age, reducing vaccine virus dosage by 40%, 60%, or 80% led to progressive and statistically significant reductions in the seroconversion rates from 89% in children receiving the full dose to a minimum value of 46%. Reducing the volume of the inoculum below the standard of 0.5 ml resulted in a further reduction of seroconversion rates at each antigen dose level. Seroconversion rates in all dosage groups were lower for children below 12 months of age. These data suggest that dose reduction would not be a satisfactory economy measure in measles vaccination campaigns.
为评估减毒活麻疹疫苗（施瓦茨株）低剂量的有效性，通过喷射注射器对尼日利亚西北部农村地区967名7至30个月大的血清阴性儿童接种了不同剂量的该疫苗。对于12个月以上的儿童，将疫苗病毒剂量降低40%、60%或80%，会导致血清转化率逐渐且有统计学意义地降低，从接受全剂量疫苗儿童的89%降至最低值46%。将接种量降至低于0.5毫升的标准，会导致每个抗原剂量水平的血清转化率进一步降低。12个月以下儿童在所有剂量组中的血清转化率均较低。这些数据表明，在麻疹疫苗接种运动中，减少剂量并非令人满意的节约措施。
