Buck G M, Vena J E, Schisterman E F, Dmochowski J, Mendola P, Sever L E, Fitzgerald E, Kostyniak P, Greizerstein H, Olson J
Department of Social and Preventive Medicine, University at Buffalo, State University of New York 14214, USA.
Epidemiology. 2000 Jul;11(4):388-93. doi: 10.1097/00001648-200007000-00005.
Wildlife studies suggest that consumption of contaminated fish from the Great Lakes may expose humans to polychlorinated biphenyls and persistent chlorinated pesticides. To assess whether time to pregnancy or fecundability is affected, we conducted a telephone survey in 1993 with female members of the New York State Angler Cohort Study who were considering pregnancy between 1991 and 1994 (N = 2,445). Among the 1,234 (50%) women who became pregnant, 895 (73%) had a known time to pregnancy. Upon enrollment into the cohort in 1991, both partners reported duration and frequency of Lake Ontario sport fish consumption. We estimated lifetime exposure to polychlorinated biphenyls from recent consumption and used a discrete-time analog of Cox proportional hazards analysis to estimate conditional fecundability ratios and 95% confidence intervals (CIs) for fish consumption among couples with complete exposure data who discontinued birth control to become pregnant (N = 575). Maternal consumption of fish for 3-6 years was associated with reduced fecundability (fecundability ratio = 0.75; 95% CI = 0.59-0.91), as was more than a monthly fish meal in 1991 (fecundability ratio = 0.73; 95% CI = 0.54-0.98). Our findings suggest that maternal but not paternal consumption of contaminated fish may reduce fecundability among couples attempting pregnancy.
野生动物研究表明，食用五大湖受污染的鱼类可能会使人类接触到多氯联苯和持久性氯代农药。为了评估怀孕时间或受孕能力是否受到影响，我们于1993年对纽约州垂钓者队列研究中的女性成员进行了电话调查，这些女性在1991年至1994年期间考虑怀孕（N = 2445）。在1234名（50%）怀孕的女性中，895名（73%）有已知的怀孕时间。1991年进入队列时，夫妻双方都报告了安大略湖食用游钓鱼类的时长和频率。我们估计了近期食用多氯联苯的终生暴露量，并使用Cox比例风险分析的离散时间模拟方法，来估计在停止避孕以怀孕的、有完整暴露数据的夫妻中（N = 575），食用鱼类的条件受孕能力比率和95%置信区间（CI）。母亲食用鱼类3至6年与受孕能力降低有关（受孕能力比率 = 0.75；95% CI = 0.59 - 0.91），1991年每月食用鱼类超过一次也有此关联（受孕能力比率 = 0.73；95% CI = 0.54 - 0.98）。我们的研究结果表明，尝试怀孕的夫妻中，母亲而非父亲食用受污染的鱼类可能会降低受孕能力。
