Yip J W, Yip Y P, Nakajima K, Capriotti C
Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8612-6. doi: 10.1073/pnas.150040497.
Mutation of the reeler gene (Reln) disrupts neuronal migration in several brain regions and gives rise to functional deficits such as ataxic gait and trembling in the reeler mutant mouse. Thus, the Reln product, reelin, is thought to control cell-cell interactions critical for cell positioning in the brain. Although an abundance of reelin transcript is found in the embryonic spinal cord [Ikeda, Y. & Terashima, T. (1997) Dev. Dyn. 210, 157-172; Schiffmann, S. N., Bernier, B. & Goffinet, A. M. (1997) Eur. J. Neurosci. 9, 1055-1071], it is generally thought that neuronal migration in the spinal cord is not affected by reelin. Here, however, we show that migration of sympathetic preganglionic neurons in the spinal cord is affected by reelin. This study thus indicates that reelin affects neuronal migration outside of the brain. Moreover, the relationship between reelin and migrating preganglionic neurons suggests that reelin acts as a barrier to neuronal migration.
瑞立基因（Reln）的突变会破坏多个脑区的神经元迁移，并在瑞立突变小鼠中引发共济失调步态和颤抖等功能缺陷。因此，人们认为瑞立基因的产物——瑞立蛋白，能够控制对大脑中细胞定位至关重要的细胞间相互作用。尽管在胚胎脊髓中发现了大量的瑞立转录本[池田洋和寺岛敏（1997年），《发育动力学》第210卷，第157 - 172页；希夫曼，S. N.、伯尼尔，B.和戈菲内，A. M.（1997年），《欧洲神经科学杂志》第9卷，第1055 - 1071页]，但一般认为脊髓中的神经元迁移不受瑞立蛋白影响。然而，我们在此表明，脊髓中交感节前神经元的迁移受瑞立蛋白影响。因此，本研究表明瑞立蛋白会影响脑外的神经元迁移。此外，瑞立蛋白与迁移的节前神经元之间的关系表明，瑞立蛋白起到了神经元迁移屏障的作用。
