Matsumoto K, Yoshikawa H, Nakagawa S, Tang X, Yasugi T, Kawana K, Sekiya S, Hirai Y, Kukimoto I, Kanda T, Taketani Y
Department of Obstetrics and Gynecology, University of Tokyo, 1-7-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan.
Cancer Lett. 2000 Aug 11;156(2):159-65. doi: 10.1016/s0304-3835(00)00457-2.
To investigate whether HPV16 E6 variants carry an elevated risk for cervical cancer in Japanese population, we investigated the E6 sequence variation in 40 cervical intraepithelial neoplasias (CINs) I-III and 43 invasive cervical cancers (ICCs), all positive for HPV16. HPV16 E6 variants were frequently found in ICCs than in CINs (88 vs. 65%, P=0.01). The E6 D25E, a rare variant in Western countries, was most frequently observed in ICC (44%). CIN I/II lesions with HPV16 variants were less likely to regress than those with HPV16 prototype (P=0.048). The finding that HPV16 E6 variants represent a significant risk factor is common between Western and Japanese women despite the different distribution of each variant.
为了研究HPV16 E6变异体在日本人群中是否会增加患宫颈癌的风险，我们调查了40例HPV16阳性的宫颈上皮内瘤变（CIN）I - III级和43例浸润性宫颈癌（ICC）中的E6序列变异情况。在ICC中比在CIN中更频繁地发现HPV16 E6变异体（88%对65%，P = 0.01）。E6 D25E这种在西方国家罕见的变异体，在ICC中最常被观察到（44%）。与HPV16原型的CIN I/II病变相比，携带HPV16变异体的CIN I/II病变消退的可能性较小（P = 0.048）。尽管每种变异体的分布不同，但HPV16 E6变异体是一个重要风险因素这一发现，在西方女性和日本女性中是共同的。
