Xin C Y, Matsumoto K, Yoshikawa H, Yasugi T, Onda T, Nakagawa S, Yamada M, Nozawa S, Sekiya S, Hirai Y, Shiromizu K, Fujii T, Taketani Y
Department of Obstetrics and Gynecology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan.
Cancer Lett. 2001 Sep 10;170(1):19-24. doi: 10.1016/s0304-3835(01)00570-5.
The variation of the E6 region of human papillomavirus type 16 (HPV16) is associated with a high risk for cervical carcinogenesis. To see whether the same is the case with HPV33, 52 and 58, known to have high homology with HPV16, we analyzed the E6 sequence variation of these HPVs in 107 Japanese women with cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC): 20 HPV33-positive, 46 HPV52-positive and 41 HPV58-positive cases. HPV33 variants were more frequently observed in CINs I/II than in CIN III/ICCs (71% (5/7) versus 15% (2/13), P=0.02). In HPV52-positive cases, a single E6 variant was detected in 98% of the cases, whereas the prototype accounted for 98% of HPV58-positive cases. In summary, the distribution of E6 variants is different among HPV types tested, suggesting a link between E6 variation and oncogenic potential being type-specific.
人乳头瘤病毒16型（HPV16）E6区域的变异与宫颈癌发生的高风险相关。为了探究与HPV16具有高度同源性的HPV33、52和58是否也是如此，我们分析了107例患有宫颈上皮内瘤变（CIN）或浸润性宫颈癌（ICC）的日本女性中这些HPV的E6序列变异情况：20例HPV33阳性、46例HPV52阳性和41例HPV58阳性病例。在CIN I/II中观察到HPV33变异体的频率高于CIN III/ICC（71%（5/7）对15%（2/13），P = 0.02）。在HPV52阳性病例中，98%的病例检测到单一E6变异体，而原型在HPV58阳性病例中占98%。总之，在所检测的HPV类型中E6变异体的分布不同，这表明E6变异与致癌潜能之间的联系具有型特异性。
