Guerra B, Soto S, Cal S, Mendoza M C
Area de Microbiología, Departamento de Biología Funcional, Universidad de Oviedo, Principado de Asturias, Spain.
Antimicrob Agents Chemother. 2000 Aug;44(8):2166-9. doi: 10.1128/AAC.44.8.2166-2169.2000.
The resistance profiles, for 15 antimicrobial agents, of 333 Salmonella strains representing the most frequent nontyphoidal serotypes, isolated between 1989 and 1998 in a Spanish region, and 9 reference strains were analyzed. All strains were susceptible to amikacin, ceftazidime, ciprofloxacin, and imipenem, and 31% were susceptible to all antimicrobials tested. The most frequent types of resistance were to sulfadiazine, tetracycline, streptomycin, spectinomycin, ampicillin, and chloramphenicol (ranging from 46 to 22%); 13% were resistant to these six drugs. This multidrug resistance pattern was found alone or together with other resistance types within serotypes Typhimurium (45%), Panama (23%), and Virchow (4%). Each isolate was also screened for the presence of class 1 integrons and selected resistance genes therein; seven variable regions which carried one (aadA1a, aadA2, or pse-1) or two (dfrA14-aadA1a, dfrA1-aadA1a, oxa1-aadA1a, or sat1-aadA1a) resistance genes were found in integrons.
对1989年至1998年间在西班牙一个地区分离出的代表最常见非伤寒血清型的333株沙门氏菌菌株以及9株参考菌株，分析了它们对15种抗菌药物的耐药谱。所有菌株对阿米卡星、头孢他啶、环丙沙星和亚胺培南敏感，31%的菌株对所有测试抗菌药物敏感。最常见的耐药类型是对磺胺嘧啶、四环素、链霉素、大观霉素、氨苄西林和氯霉素（范围从46%至22%）；13%的菌株对这六种药物耐药。这种多重耐药模式在鼠伤寒血清型（45%）、巴拿马血清型（23%）和维尔肖血清型（4%）中单独或与其他耐药类型一起被发现。还对每个分离株进行了1类整合子的检测以及其中选定耐药基因的筛查；在整合子中发现了七个可变区，这些可变区携带一个（aadA1a、aadA2或pse-1）或两个（dfrA14-aadA1a、dfrA1-aadA1a、oxa1-aadA1a或sat1-aadA1a）耐药基因。
