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对幽门螺杆菌感染的显性无反应性与白细胞介素10的产生有关，而与γ干扰素无关。

Dominant nonresponsiveness to Helicobacter pylori infection is associated with production of interleukin 10 but not gamma interferon.

作者信息

Sutton P, Kolesnikow T, Danon S, Wilson J, Lee A

机构信息

School of Microbiology and Immunology, University of New South Wales, Sydney, New South Wales 2052, Australia.

出版信息

Infect Immun. 2000 Aug;68(8):4802-4. doi: 10.1128/IAI.68.8.4802-4804.2000.

DOI:10.1128/IAI.68.8.4802-4804.2000
PMID:10899893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC98442/
Abstract

Helicobacter pylori-induced gastritis is an essential precursor lesion for the development of peptic ulcers or gastric adenocarcinoma. We demonstrate that nonresponsiveness to H. pylori SS1 infection is dominantly inherited in mice. F(1) hybrid crosses between a nonresponder mouse and three responder strains all possessed the nonresponder phenotype. Secretion of interleukin-10 but not gamma interferon was associated with nonresponsiveness to infection.

摘要

幽门螺杆菌诱导的胃炎是消化性溃疡或胃腺癌发生的重要前期病变。我们证明，对幽门螺杆菌SS1感染无反应性在小鼠中呈显性遗传。无反应性小鼠与三个有反应性品系之间的F(1)杂种杂交后代均具有无反应性表型。白细胞介素-10而非γ干扰素的分泌与对感染的无反应性相关。

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本文引用的文献

1
A genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F(1) hybrid mice.萎缩的遗传基础：F1 杂交小鼠中的显性无反应性和幽门螺杆菌诱导的胃炎
Gut. 1999 Sep;45(3):335-40. doi: 10.1136/gut.45.3.335.
2
Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model.γ干扰素在小鼠模型中幽门螺杆菌诱导的胃炎症反应中的作用
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Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism.肝螺杆菌通过白细胞介素-12（IL-12）和γ干扰素依赖性机制，在无特定病原体的白细胞介素-10（IL-10）缺陷小鼠中引发结肠炎。
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Acta Med Okayama. 1998 Feb;52(1):41-8. doi: 10.18926/AMO/31337.
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The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection.HLA-DQA1基因在幽门螺杆菌感染诱导的萎缩性胃炎和胃腺癌抗性中的作用。
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Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype.幽门螺杆菌感染时，人胃黏膜中的淋巴细胞具有辅助性T细胞1表型。
Gastroenterology. 1998 Mar;114(3):482-92. doi: 10.1016/s0016-5085(98)70531-1.
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Evaluation of the aetiological role of dietary salt exposure in gastric and other cancers in humans.
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