Seabrook T J, Hein W R, Dudler L, Young A J
Basel Institute for Immunology, Switzerland.
Blood. 2000 Aug 1;96(3):1180-3.
The spleen plays a major role in immune surveillance, but the impact that splenectomy exerts on the immune competence of an individual is not fully resolved. Here we show that neonatal splenectomy in sheep does not abrogate the development of a large, nonrecirculating pool of lymphocytes and that it has no effect on the acquisition of a normal blood lymphocyte profile. Splenectomy did, however, result in a significant decrease in blood residency time of recirculating lymphocytes and in an enhanced accumulation of recirculating lymphocytes in lymph nodes. Furthermore, nonrecirculating peripheral blood lymphocytes were less likely to migrate to the lung, possibly because of saturation of the marginal pool by recirculating lymphocytes. Although splenectomy has little effect on the development or distribution of lymphocyte subsets in blood and lymph, it has marked effects on the rate of recirculation of lymphocytes, which may have significant implications for peripheral immune surveillance in patients who undergo splenectomy.
脾脏在免疫监视中起主要作用，但脾切除术对个体免疫能力的影响尚未完全明确。在此我们表明，新生绵羊的脾切除术不会消除大量非循环淋巴细胞池的发育，且对正常血液淋巴细胞谱的获得没有影响。然而，脾切除术确实导致循环淋巴细胞在血液中的驻留时间显著缩短，以及循环淋巴细胞在淋巴结中的积聚增加。此外，非循环外周血淋巴细胞迁移至肺部的可能性较小，这可能是由于循环淋巴细胞使边缘池饱和所致。尽管脾切除术对血液和淋巴中淋巴细胞亚群的发育或分布影响不大，但对淋巴细胞的再循环速率有显著影响，这可能对接受脾切除术的患者的外周免疫监视具有重要意义。
