Barykina N N, Kolpakov V G, Alekhina T A, Chuguy V F, Axenovich T I
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Behav Genet. 2000 Jan;30(1):77-81. doi: 10.1023/a:1002094728510.
The stereotyped hyperkinesis referred to as pendulum movements (PM) may be found in up to 50% of the animals in stocks of Wistar rats. The mode of inheritance of predisposition to PM was studied by two methods: 1) a classical Mendelian analysis of hybrids of the strains PM+ and PM- bred from Wistar stock for enhancement and absence of PM, respectively, and 2) a segregation analysis of pedigree data from the archive records of breeding the cataleptic GC strain. The two methods gave the same result: the inheritance of predisposition to PM can be explained by a major gene model with an incomplete penetrance of heterozygous genotype.
在Wistar大鼠种群中，高达50%的动物可能会出现被称为摆动运动（PM）的刻板性运动亢进。通过两种方法研究了对PM易感性的遗传模式：1）对分别从Wistar种群培育的PM+和PM-品系杂种进行经典孟德尔分析，以观察PM的增强和缺失情况；2）对僵住GC品系繁殖档案记录中的系谱数据进行分离分析。两种方法得出了相同的结果：对PM易感性的遗传可以用杂合基因型不完全显性的主基因模型来解释。
