Holm C, Osterlund T, Laurell H, Contreras J A
Department of Cell and Molecular Biology, Section for Molecular Signalling, Lund University, Lund, Sweden.
Annu Rev Nutr. 2000;20:365-93. doi: 10.1146/annurev.nutr.20.1.365.
Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a pivotal role in lipid metabolism, overall energy homeostasis, and, presumably, cellular events involving fatty acid signaling. Detailed knowledge about its structure and regulation may provide information regarding the pathogenesis of such human diseases as obesity and diabetes and may generate concepts for new treatments of these diseases. The current review summarizes the recent advances with regard to hormone-sensitive lipase structure and molecular mechanisms involved in regulating its activity and lipolysis in general. A summary of the current knowledge regarding regulation of expression, potential involvement in lipid disorders, and role in tissues other than adipose tissue is also provided.
激素敏感性脂肪酶是细胞内甘油三酯水解的限速酶，是脂肪组织以及其他组织中脂肪酸动员的主要决定因素。它在脂质代谢、整体能量稳态以及可能涉及脂肪酸信号传导的细胞事件中起着关键作用。关于其结构和调节的详细知识可能为肥胖和糖尿病等人类疾病的发病机制提供信息，并可能产生这些疾病新治疗方法的概念。本综述总结了激素敏感性脂肪酶结构以及一般调节其活性和脂解的分子机制方面的最新进展。还提供了关于其表达调节、在脂质紊乱中的潜在作用以及在脂肪组织以外组织中的作用的当前知识总结。
