Beysens D A, Forgacs G, Glazier J A
ESEME-Service des Basses Temperatures, Commissariat à l'Energie Atomique, Grenoble, France.
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9467-71. doi: 10.1073/pnas.97.17.9467.
Morphogenetic processes, like sorting or spreading of tissues, characterize early embryonic development. An analogy between viscoelastic fluids and certain properties of embryonic tissues helps interpret these phenomena. The values of tissue-specific surface tensions are consistent with the equilibrium configurations that the Differential Adhesion Hypothesis predicts such tissues reach after sorting and spreading. Here we extend the fluid analogy to cellular kinetics. The same formalism applies to recent experiments on the kinetics of phase ordering in two-phase fluids. Our results provide biologically relevant information on the strength of binding between cell adhesion molecules under near-physiological conditions.
形态发生过程,如组织的分选或铺展,是早期胚胎发育的特征。粘弹性流体与胚胎组织的某些特性之间的类比有助于解释这些现象。组织特异性表面张力的值与差异粘附假说预测此类组织在分选和铺展后达到的平衡构型一致。在这里,我们将流体类比扩展到细胞动力学。相同的形式体系适用于最近关于两相流体中相序动力学的实验。我们的结果提供了在近生理条件下细胞粘附分子之间结合强度的生物学相关信息。