用抗体和补体对感染约氏疟原虫的小鼠红细胞进行特异性裂解。
Specific lysis of Plasmodium yoelii infected mouse erythrocytes with antibody and complement.
作者信息
Gabriel J, Berzins K
出版信息
Clin Exp Immunol. 1983 Apr;52(1):129-34.
Abstract
An assay for complement-dependent antibody-mediated cytolysis of Plasmodium yoelii infected mouse erythrocytes was designed. By means of a rat hyperimmune serum to P. yoelii the presence of parasite associated antigens was demonstrated on erythrocytes from P. yoelii infected mice. Tests with such erythrocytes fractionated on Percoll gradients showed that the target antigens for the cytotoxic antibodies were confined to the surface of only infected erythrocytes containing late stages of the parasite. The cytotoxic antibodies were of IgG class.
摘要
设计了一种针对约氏疟原虫感染小鼠红细胞的补体依赖性抗体介导的细胞溶解试验。借助针对约氏疟原虫的大鼠超免疫血清，在约氏疟原虫感染小鼠的红细胞上证实了寄生虫相关抗原的存在。用在Percoll梯度上分级分离的此类红细胞进行的试验表明，细胞毒性抗体的靶抗原仅限于含有寄生虫晚期的受感染红细胞表面。细胞毒性抗体属于IgG类。
相似文献
1
Specific lysis of Plasmodium yoelii infected mouse erythrocytes with antibody and complement.用抗体和补体对感染约氏疟原虫的小鼠红细胞进行特异性裂解。
Clin Exp Immunol. 1983 Apr;52(1):129-34.
2
3
Oxidative killing of the intraerythrocytic malaria parasite Plasmodium yoelii by activated macrophages.活化巨噬细胞对红细胞内疟原虫约氏疟原虫的氧化杀伤作用。
J Immunol. 1984 Jan;132(1):424-31.
4
5
Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen.用纯化的约氏疟原虫裂殖体抗原免疫的BALB/c小鼠的保护性反应特征。
Clin Exp Immunol. 1983 Dec;54(3):609-16.
6
Antibodies from malaria-exposed pregnant women recognize trypsin resistant epitopes on the surface of Plasmodium falciparum-infected erythrocytes selected for adhesion to chondroitin sulphate A.来自接触过疟疾的孕妇的抗体能够识别恶性疟原虫感染的红细胞表面上对胰蛋白酶具有抗性的表位，这些红细胞是被选择用于黏附硫酸软骨素A的。
Malar J. 2004 Sep 6;3:31. doi: 10.1186/1475-2875-3-31.
7
Plasmodium yoelii: experimental evidences for the conserved epitopes between mouse and human malaria parasite, Plasmodium falciparum.约氏疟原虫：小鼠疟原虫与人疟原虫恶性疟原虫之间保守表位的实验证据
Exp Parasitol. 2007 Jul;116(3):214-24. doi: 10.1016/j.exppara.2007.01.012. Epub 2007 Jan 27.
8
Study on protective immunity against infection of Plasmodium yoelii 17XL in DBA/2 mice.DBA/2小鼠对约氏疟原虫17XL感染的保护性免疫研究。
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006 Feb 28;24(1):14-8.
9
Splenic mediated erythrocyte cytotoxicity in malaria.疟疾中脾脏介导的红细胞细胞毒性
Immunology. 1975 Jul;29(1):49-54.
10
Experimental malaria in the CBA/N mouse.CBA/N小鼠的实验性疟疾
J Immunol. 1979 Dec;123(6):2532-9.
引用本文的文献
1
The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.C5 转化酶在鼠实验性脑型疟疾中并非末端补体途径激活所必需。
J Biol Chem. 2012 Jul 13;287(29):24734-8. doi: 10.1074/jbc.C112.378364. Epub 2012 Jun 11.
2
Complement contributes to protective immunity against reinfection by Plasmodium chabaudi chabaudi parasites.补体有助于对恰氏疟原虫寄生虫再感染产生保护性免疫。
Infect Immun. 2001 Jun;69(6):3853-9. doi: 10.1128/IAI.69.6.3853-3859.2001.
3
Possible role of specific immunoglobulin M antibodies to Plasmodium falciparum antigens in immunoprotection of humans living in a hyperendemic area, Burkina Faso.特定免疫球蛋白M抗体对恶性疟原虫抗原在布基纳法索高度流行地区人群免疫保护中的可能作用
J Clin Microbiol. 1993 Mar;31(3):636-41. doi: 10.1128/jcm.31.3.636-641.1993.
4
Surface antigen expression on Plasmodium falciparum-infected erythrocytes is modified in alpha- and beta-thalassemia.在α和β地中海贫血中，恶性疟原虫感染的红细胞上的表面抗原表达会发生改变。
J Exp Med. 1991 Apr 1;173(4):785-91. doi: 10.1084/jem.173.4.785.
本文引用的文献
1
Immune phagocytosis of Plasmodium yoelii-infected erythrocytes by macrophages and eosinophils.巨噬细胞和嗜酸性粒细胞对约氏疟原虫感染红细胞的免疫吞噬作用。
Clin Exp Immunol. 1980 Oct;42(1):114-20.
2
Characterization of surface proteins and glycoproteins on red blood cells from mice infected with haemosporidia: Plasmodium yoelii infections of BALB/c mice.感染血孢子虫的小鼠红细胞表面蛋白和糖蛋白的特征：BALB/c小鼠的约氏疟原虫感染
Parasitology. 1980 Oct;81(2):299-314. doi: 10.1017/s0031182000056043.
3
Killing of the malarial parasite Plasmodium yoelii in vitro by cells of myeloid origin.髓系来源的细胞在体外对疟原虫约氏疟原虫的杀伤作用。
Parasite Immunol. 1982 Mar;4(2):77-91. doi: 10.1111/j.1365-3024.1982.tb00421.x.
4
Opsonic activity of human immune serum on in vitro phagocytosis of Plasmodium falciparum infected red blood cells by monocytes.人免疫血清对单核细胞体外吞噬恶性疟原虫感染红细胞的调理活性。
Clin Exp Immunol. 1982 Mar;47(3):635-44.
5
Surface proteins of schizont-infected erythrocytes and merozoites of Plasmodium falciparum.恶性疟原虫裂殖体感染的红细胞和裂殖子的表面蛋白。
Mol Biochem Parasitol. 1982 Jan;5(1):55-64. doi: 10.1016/0166-6851(82)90006-8.
6
Identification of a schizont- and species-specific surface glycoprotein on erythrocytes infected with rodent malarias.在感染啮齿动物疟疾的红细胞上鉴定一种裂殖体和物种特异性表面糖蛋白。
Mol Biochem Parasitol. 1982 Jan;5(1):45-54. doi: 10.1016/0166-6851(82)90005-6.
7
The binding of antibodies from Plasmodium berghei-infected rats to isoantigenic and parasite-specific antigenic sites on the surfaces of infected reticulocytes.来自感染伯氏疟原虫大鼠的抗体与感染的网织红细胞表面的同种抗原和寄生虫特异性抗原位点的结合。
Parasite Immunol. 1982 Jan;4(1):21-31. doi: 10.1111/j.1365-3024.1982.tb00417.x.
8
9
Characterization of surface proteins and glycoproteins on red blood cells from mice infected with haemosporidia: Plasmodium berghei infections of BALB/c mice.感染血孢子虫的小鼠红细胞表面蛋白和糖蛋白的特征：BALB/c小鼠的伯氏疟原虫感染
Parasitology. 1980 Oct;81(2):273-98. doi: 10.1017/s0031182000056031.
10
Specific antibody-dependent cellular cytotoxicity in human malaria.人类疟疾中的特异性抗体依赖性细胞毒性
Clin Exp Immunol. 1980 Sep;41(3):423-9.
Zotero 插件