用抗体和补体对感染约氏疟原虫的小鼠红细胞进行特异性裂解。
Specific lysis of Plasmodium yoelii infected mouse erythrocytes with antibody and complement.
作者信息
Gabriel J, Berzins K
出版信息
Clin Exp Immunol. 1983 Apr;52(1):129-34.
Abstract
An assay for complement-dependent antibody-mediated cytolysis of Plasmodium yoelii infected mouse erythrocytes was designed. By means of a rat hyperimmune serum to P. yoelii the presence of parasite associated antigens was demonstrated on erythrocytes from P. yoelii infected mice. Tests with such erythrocytes fractionated on Percoll gradients showed that the target antigens for the cytotoxic antibodies were confined to the surface of only infected erythrocytes containing late stages of the parasite. The cytotoxic antibodies were of IgG class.
摘要
设计了一种针对约氏疟原虫感染小鼠红细胞的补体依赖性抗体介导的细胞溶解试验。借助针对约氏疟原虫的大鼠超免疫血清，在约氏疟原虫感染小鼠的红细胞上证实了寄生虫相关抗原的存在。用在Percoll梯度上分级分离的此类红细胞进行的试验表明，细胞毒性抗体的靶抗原仅限于含有寄生虫晚期的受感染红细胞表面。细胞毒性抗体属于IgG类。
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