脓毒性休克期间的亚硝酸盐/硝酸盐（NOx）水平及血流动力学

Nitrite/nitrate (NOx) levels and hemodynamics during septic shock.

作者信息

Nakae H, Endo S, Kikuchi M, Yamada Y, Shibata M, Ishikura H, Tanaka T, Wakabayashi G, Kawamura T, Inada K, Sato S

机构信息

Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.

出版信息

Surg Today. 2000;30(8):683-8. doi: 10.1007/s005950070078.

DOI:10.1007/s005950070078

PMID:10955729

Abstract

Nitric oxide (NO) acts as a vasorelaxant. We investigated the relationship between nitrite/nitrate (NOx), which are the final metabolites of NO, and hemodynamics during septic shock. We also examined tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), and endotoxin. A significant negative correlation was observed between NOx levels and pulmonary capillary wedge pressure (PCWP; r = -0.6075, P = 0.0028). A significant positive correlation was noted between NOx levels and the cardiac index (CI; r = 0.5934, P = 0.0038). A significant negative correlation was found between NOx levels and the systemic vascular resistance index (SVRI; r = -0.4354, P = 0.0485). A significant positive correlation was observed between NOx levels and the stroke volume index (SVI; r = 0.5040, P = 0.0186). A significantly close positive correlation was also observed between TNF-alpha levels and NOx levels (r = 0.7848, P < 0.0001). These findings suggest that NOx levels are closely associated with hemodynamics during septic shock, resulting in a vascular relaxing effect.

摘要

一氧化氮（NO）具有血管舒张作用。我们研究了作为NO最终代谢产物的亚硝酸盐/硝酸盐（NOx）与脓毒性休克期间血流动力学之间的关系。我们还检测了肿瘤坏死因子α（TNF-α）、白细胞介素-8（IL-8）和内毒素。观察到NOx水平与肺毛细血管楔压（PCWP；r = -0.6075，P = 0.0028）之间存在显著负相关。NOx水平与心脏指数（CI；r = 0.5934，P = 0.0038）之间存在显著正相关。NOx水平与全身血管阻力指数（SVRI；r = -0.4354，P = 0.0485）之间存在显著负相关。NOx水平与每搏输出量指数（SVI；r = 0.5040，P = 0.0186）之间存在显著正相关。TNF-α水平与NOx水平之间也观察到显著密切的正相关（r = 0.7848，P < 0.0001）。这些发现表明，NOx水平与脓毒性休克期间的血流动力学密切相关，从而产生血管舒张作用。