Revill S M, Singh S J, Morgan M D
Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK.
Respir Med. 2000 Aug;94(8):778-83. doi: 10.1053/rmed.2000.0824.
In a prospective, randomized study we examined the effect of (i) ambulatory oxygen and (ii) a portable, inspiratory pressure support (IPS) device on the endurance shuttle walk test (ESWT) in patients with severe chronic obstructive pulmonary disease (COPD). Ten outpatients [median (range) FEV1 0.60 l(0.35, 1.45)] performed the ESWT under five test conditions: baseline walk (no assistance), IPS at 14 cmH2O from a portable ventilator (the HIPPY, Friday Medical, U.K.), sham IPS (< 8 cmH2O), ambulatory oxygen at 2 l min(-1), and sham oxygen (carrying the portable oxygen cylinder and breathing air). There were significant improvements in the ESWT with ambulatory oxygen, but a negative effect with the HIPPY device [mean (SD) time: baseline 172 (48) sec; oxygen 242 (62) sec; HIPPY 84 (35) sec]. The ESWT appeared sensitive to the effect of cylinder weight although differences in endurance capacity were not significant [sham oxygen 151 (45) sec]. The ESWT was sensitive to the acute application of oxygen, demonstrating a beneficial effect on endurance performance in patients with severe COPD. The ESWT could form the basis of a standardized assessment for ambulatory oxygen.
在一项前瞻性随机研究中，我们考察了（i）非卧床吸氧和（ii）一种便携式吸气压力支持（IPS）设备对重度慢性阻塞性肺疾病（COPD）患者耐力穿梭步行试验（ESWT）的影响。10名门诊患者[中位数（范围）第1秒用力呼气容积为0.60升（0.35，1.45）]在五种测试条件下进行了ESWT：基线步行（无辅助）、来自便携式呼吸机（英国星期五医疗公司的HIPPY）的14厘米水柱的IPS、假IPS（<8厘米水柱）、2升/分钟的非卧床吸氧以及假吸氧（携带便携式氧气瓶并呼吸空气）。非卧床吸氧使ESWT有显著改善，但HIPPY设备有负面影响[平均（标准差）时间：基线172（48）秒；吸氧242（62）秒；HIPPY 84（35）秒]。尽管耐力能力差异不显著[假吸氧151（45）秒]，ESWT似乎对气瓶重量的影响敏感。ESWT对急性吸氧敏感，显示出对重度COPD患者耐力表现有有益作用。ESWT可构成非卧床吸氧标准化评估的基础。
