通过小鼠Vκ基因座中的A基因确定κ抗α(1,3)葡聚糖免疫反应差异。
Determination of the kappa anti-alpha(1,3) dextran immune response difference by A gene(s) in the VKappa-locus of mice.
作者信息
de Preval C, Blomberg B, Cohn M
出版信息
J Exp Med. 1979 May 1;149(5):1265-70. doi: 10.1084/jem.149.5.1265.
Abstract
Mice lacking the V(alpha(1,3) (h gamma1)-gene do not produce a gamma1 anti-alpha(1,3) dextran response. However, on hyperimmunization some strains mount a kappa-anti-alpha(1,3) dextran response, whereas other remain nonresponder. Responsiveness in dominant. The kappa-anti-alpha(1,3) response difference is linked to the Ly-3 locus on chromosone 6 and is likely the result of a structural Vkappa-gene(s). In conjunction with previous work, three Vkappa-allogroups can now be distinguished. At present, this is the only example of an immune responsiveness difference associated with the Vkappa-locus.
摘要
缺乏V(α(1,3) (hγ1)-基因的小鼠不会产生γ1抗α(1,3)葡聚糖反应。然而，在超免疫时，一些品系会产生κ抗α(1,3)葡聚糖反应，而其他品系则仍无反应。反应性具有显性。κ抗α(1,3)反应差异与6号染色体上的Ly-3位点相关，可能是一个或多个Vκ基因结构的结果。结合先前的研究工作，现在可以区分出三个Vκ同种异型组。目前，这是与Vκ位点相关的免疫反应性差异的唯一例子。
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