小鼠轻链可变区标记与胸腺细胞表面抗原的遗传相关性。
Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.
作者信息
Gottlieb P D
出版信息
J Exp Med. 1974 Nov 1;140(5):1432-7. doi: 10.1084/jem.140.5.1432.
Abstract
The inbred and congenic strain distribution of the I(H)-peptide marker in the variable region of mouse immunoglobulin light chains has been compared with other known genetic markers. A positive correlation was noted between the I(H)-peptide marker and expression of the Ly-3.1 thymocyte cell surface antigen. This suggests that the locus responsible for I(H)-peptide expression is genetically linked to the Ly-2 and Ly-3 loci in linkage group XI on chromsome 6 of the mouse.
摘要
已将小鼠免疫球蛋白轻链可变区中I(H)肽标记的近交系和同源系分布与其他已知遗传标记进行了比较。发现I(H)肽标记与Ly-3.1胸腺细胞表面抗原的表达之间存在正相关。这表明负责I(H)肽表达的基因座在遗传上与小鼠6号染色体连锁群XI中的Ly-2和Ly-3基因座相关。
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本文引用的文献
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Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.Ly-C：第三个基因座，它决定了仅在胸腺细胞和淋巴细胞上表达的同种异体抗原。
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2
A genetic marker in the variable region of light chains of mouse immunoglobulins.小鼠免疫球蛋白轻链可变区中的一种遗传标记。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1192-9. doi: 10.1073/pnas.67.3.1192.
3
An approach to the mapping of antigens on the cell surface.一种绘制细胞表面抗原图谱的方法。
Proc Natl Acad Sci U S A. 1968 Jul;60(3):886-93. doi: 10.1073/pnas.60.3.886.
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