免疫调节回路的基因控制。与免疫球蛋白（Ig）基因座相关的基因调控调节性T细胞亚群之间的通讯。
Genetic control of immunoregulatory circuits. Genes linked to the Ig locus govern communication between regulatory T-cell sets.
作者信息
Eardley D D, Shen F W, Cantor H, Gershon R K
出版信息
J Exp Med. 1979 Jul 1;150(1):44-50. doi: 10.1084/jem.150.1.44.
Abstract
Antigen-stimulated Ly1:Qa1+ cells induce a nonimmune set of T-acceptor cells (surface phenotype Ly123+Qa1+) to participate in the generation of specific suppressive activity. The experiments reported here were designed to test the possibility that the interaction between T-inducer and T-acceptor cells might be governed by genes linked to the Ig locus. We find that inducer:acceptor interactions occur only if the inducer and acceptor T-cell sets are obtained from donor that are identical at the Ig locus and are independent of the Ig locus expressed on the B cells used for assay of T-helper activity. In addition, experiments using inducer and acceptor T cells from the congenic recombinant BAB. 14 strain show that T-T interactions are not governed by Ig-CH genes, per se. These data indicate that T-inducer: T-acceptor interactions are governed by Ig-linked genes that may control expression of VH-like structures on T cells, or control expression of as yet unidentified cell-surface molecules.
摘要
抗原刺激的Ly1:Qa1+细胞诱导一组非免疫性的T受体细胞（表面表型为Ly123+Qa1+）参与特异性抑制活性的产生。本文报道的实验旨在测试T诱导细胞与T受体细胞之间的相互作用可能受与Ig基因座连锁的基因调控的可能性。我们发现，只有当诱导细胞和受体T细胞系来自在Ig基因座上相同的供体，并且独立于用于检测T辅助活性的B细胞上表达的Ig基因座时，诱导细胞与受体细胞之间才会发生相互作用。此外，使用来自同源重组BAB.14品系的诱导细胞和受体T细胞进行的实验表明，T-T相互作用本身不受Ig-CH基因的调控。这些数据表明，T诱导细胞与T受体细胞之间的相互作用受与Ig连锁的基因调控，这些基因可能控制T细胞上类VH结构的表达，或控制尚未鉴定的细胞表面分子的表达。
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Genetic control of immunoregulatory circuits. Genes linked to the Ig locus govern communication between regulatory T-cell sets.免疫调节回路的基因控制。与免疫球蛋白（Ig）基因座相关的基因调控调节性T细胞亚群之间的通讯。
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Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.T细胞集之间的免疫调节回路。诱导反馈抑制的辅助性T细胞亚群的鉴定。
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Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody.诱导独特型阳性B记忆细胞分泌抗体需要独特型特异性辅助性T细胞。
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Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.T细胞集之间的免疫调节回路。II. 体内反馈抑制的生理作用：NZB小鼠中不存在。
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