Kobayashi T, Kato O, Nakashima I, Kato N
Mycopathologia. 1975 Feb 28;55(1):17-22. doi: 10.1007/BF00467085.
A close correlation was observed between body weight and length of the survival time of mice inoculated intravenously (i.v.) with Cryptococcus neoformans (p less than 0.001). An endotoxic substance of C. neoformans (Cr-ET) increased the susceptibility of mice to i.v. infection of C. neoformans only when more than 50 mug of Cr-ET was injected i.v. 24 hours before infection. Intraperitoneal (i.p.) administration of dimethyl sulfoxide which is found to enhance bacterial infection did not enhance death rate of mice infected i.p. with C. neoformans.
观察到静脉内（i.v.）接种新型隐球菌的小鼠体重与存活时间长度之间存在密切相关性（p小于0.001）。新型隐球菌的一种内毒素物质（Cr-ET）仅在感染前24小时静脉注射超过50微克Cr-ET时，才会增加小鼠对新型隐球菌静脉感染的易感性。腹膜内（i.p.）给予已发现可增强细菌感染的二甲基亚砜，并未提高腹膜内感染新型隐球菌的小鼠的死亡率。
