Gunn J S
University of Texas Health Science Center at San Antonio, Department of Microbiology, 78229-3900, USA.
Microbes Infect. 2000 Jul;2(8):907-13. doi: 10.1016/s1286-4579(00)00392-0.
Enteric bacteria are resistant to the bactericidal effects of intestinal bile, but these resistance mechanisms are not completely understood. It is becoming increasingly apparent that enteric bacteria have evolved to utilize bile as a signal for the temporal production of virulence factors and other adaptive mechanisms. A greater understanding of the resistance and response of bacteria to bile may assist the development of novel therapeutic, prevention, and diagnostic strategies to treat enteric and extraintestinal infections.
肠道细菌对肠道胆汁的杀菌作用具有抗性，但这些抗性机制尚未完全明确。越来越明显的是，肠道细菌已经进化到利用胆汁作为一种信号，用于适时产生毒力因子和其他适应性机制。对细菌对胆汁的抗性和反应有更深入的了解，可能有助于开发新的治疗、预防和诊断策略，以治疗肠道和肠外感染。
