Svendsen U G
Acta Pathol Microbiol Scand A. 1975 Mar;83(2):199-205. doi: 10.1111/j.1699-0463.1975.tb01375.x.
The effect of neonatal thymectomy on the degree and prognosis of hypertension and on the vascular lesions in rats with renal hypertension was studied. There were no differences between thymectomized and sham operated hypertensive rats. The degree of hypertension, the frequency of spontaneous death and heart infarcts were the same in both groups. The occurrence and degree of perivascular cell infiltrations, deposits of perivascular connective tissue and fibrinoid degenerations of the media were found to be the same in both the thymectomized and the sham operated hypertensive animals. The results do not support the assumption that delayed type immune reactions are important in the pathogenesis of hypertensive vascular disease in renal hypertensive rats.
研究了新生期胸腺切除对肾性高血压大鼠高血压程度及预后以及血管病变的影响。胸腺切除的高血压大鼠与假手术高血压大鼠之间无差异。两组的高血压程度、自然死亡频率和心脏梗死情况相同。发现胸腺切除和假手术的高血压动物的血管周围细胞浸润、血管周围结缔组织沉积和中膜纤维蛋白样变性的发生情况及程度均相同。这些结果不支持迟发型免疫反应在肾性高血压大鼠高血压血管疾病发病机制中起重要作用这一假设。
