Jose J K, Kuttan R
Amala Cancer Research Centre, Amala Nagar PO, Thrissur 680 553, Kerala, India.
J Ethnopharmacol. 2000 Sep;72(1-2):135-40. doi: 10.1016/s0378-8741(00)00219-1.
Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CHY) extracts were studied using carbon tetrachloride (CCl(4)) induced liver injury model in rats. EO and CHY extracts were found to inhibit the hepatotoxicity produced by acute and chronic CCl(4) administration as seen from the decreased levels of serum and liver lipid peroxides (LPO), glutamate-pyruvate transaminase (GPT), and alkaline phosphatase (ALP). Chronic CCl(4) administration was also found to produce liver fibrosis as seen from the increased levels of collagen-hydroxyproline and pathological analysis. EO and CHY extracts were found to reduce these elevated levels significantly, indicating that the extract could inhibit the induction of fibrosis in rats.
采用四氯化碳（CCl₄）诱导的大鼠肝损伤模型，研究了余甘子（EO）提取物和 chyavanaprash（CHY）提取物的保肝活性。从血清和肝脏脂质过氧化物（LPO）、谷丙转氨酶（GPT）和碱性磷酸酶（ALP）水平降低可以看出，EO 和 CHY 提取物能抑制急性和慢性给予 CCl₄ 所产生的肝毒性。从胶原-羟脯氨酸水平升高和病理分析可以看出，慢性给予 CCl₄ 还会导致肝纤维化。发现 EO 和 CHY 提取物能显著降低这些升高的水平，表明该提取物可抑制大鼠肝纤维化的诱导。
