离子载体与其他抗菌剂对厌氧菌活性的比较。
Comparison of the activity of ionophores with other antibacterial agents against anaerobes.
作者信息
Watanabe K, Watanabe J, Kuramitsu S, Maruyama H B
出版信息
Antimicrob Agents Chemother. 1981 Apr;19(4):519-25. doi: 10.1128/AAC.19.4.519.
Abstract
Representative polyethers of each group in Westley's classification and related ionophore antibiotics were examined for in vitro activity against 25 anaerobic strains. Lasalocid (X-537A) and nigericin were found to have activity comparable in potency to some leading antianaerobe antibiotics, newer cephalosporins and nitroimidazoles, with a different spectrum as revealed by a spectral comparison. A strict relationship between their antianaerobe activity and either their structural features or cation transporting properties was not apparent.
摘要
对韦斯特利分类中每组的代表性聚醚及相关离子载体抗生素进行了检测，以观察其对25株厌氧菌株的体外活性。发现拉沙洛西（X-537A）和尼日利亚菌素的活性在效力上与一些主要的抗厌氧菌抗生素、新型头孢菌素和硝基咪唑相当，光谱比较显示其具有不同的光谱。它们的抗厌氧菌活性与其结构特征或阳离子转运特性之间没有明显的严格关系。
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