Centre for Research in Biosciences, Department of Applied Sciences, University of West of England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK.
Eur J Clin Microbiol Infect Dis. 2012 May;31(5):641-53. doi: 10.1007/s10096-011-1369-9. Epub 2011 Aug 2.
Due to the limitations associated with the use of existing biocidal agents, there is a need to explore new methods of disinfection to help maintain effective bioburden control, especially within the healthcare environment. The transformation of low mineral salt solutions into an activated metastable state, by electrochemical unipolar action, produces a solution containing a variety of oxidants, including hypochlorous acid, free chlorine and free radicals, known to possess antimicrobial properties. Electrochemically activated solutions (ECAS) have been shown to have broad-spectrum antimicrobial activity, and have the potential to be widely adopted within the healthcare environment due to low-cost raw material requirements and ease of production (either remotely or in situ). Numerous studies have found ECAS to be highly efficacious, as both a novel environmental decontaminant and a topical treatment agent (with low accompanying toxicity), but they are still not in widespread use, particularly within the healthcare environment. This review provides an overview of the scientific evidence for the mode of action, antimicrobial spectrum and potential healthcare-related applications of ECAS, providing an insight into these novel yet seldom utilised biocides.
由于现有杀菌剂的使用存在局限性，因此需要探索新的消毒方法来帮助维持有效的生物负荷控制，尤其是在医疗保健环境中。通过电化学单极作用，将低盐溶液转化为激活的亚稳状态，会产生一种含有多种氧化剂的溶液，包括次氯酸、游离氯和自由基，这些氧化剂具有抗菌特性。电化学激活溶液（ECAS）已被证明具有广谱抗菌活性，并且由于低成本的原材料要求和易于生产（无论是远程还是就地），有可能在医疗保健环境中得到广泛应用。许多研究发现 ECAS 非常有效，既是一种新型的环境消毒剂，也是一种局部治疗剂（伴随的毒性低），但它们仍未广泛使用，尤其是在医疗保健环境中。本综述概述了 ECAS 的作用模式、抗菌谱和潜在的与医疗保健相关的应用的科学证据，深入了解这些新颖但很少使用的杀生物剂。
