Srinivas K, Bhaskar M V, Aruna Kumari R, Nagaraj K, Reddy K K
Department of Biochemistry, Sri Venkateswara Medical College, Tirupati.
Indian Heart J. 2000 May-Jun;52(3):285-8.
The antioxidants and lipid peroxidation products are being extensively studied because of their potential importance and pathogenetic role in several non-communicable diseases like cardiovascular diseases and cancer, but the data on hypertension is scanty. Therefore, the present study aimed to assess the levels of lipid peroxidation and antioxidants besides dislipidemia changes among 32 newly diagnosed male hypertensives by comparing them with an equal sample of normotensives. Significant increase in serum lipid peroxide levels and decrease in antioxidant enzyme superoxide dismutase and vitamins E and A were observed among hypertensives than the controls. Hypertensives had higher total cholesterol, low-density lipoprotein cholesterol, triglycerides, body mass index and low high-density lipoprotein cholesterol levels than normotensives. The percentage prevalence of hypercholesterolemia, hypertriglyceridemia, low high-density lipoprotein cholesterol and obesity was higher in study subjects. Obese hypertensives had significantly higher levels of lipid peroxides and lipids with no change in antioxidant status than normal-weight hypertensives. Our results suggest that hypertensive patients may have elevated lipid peroxidation, lipids and reduced protection from antioxidants, which may contribute to the propensity in such patients to develop cardiovascular diseases, and to correct this, antioxidant supplementation besides weight reduction may be helpful to reduce the severity of burden.
抗氧化剂和脂质过氧化产物因其在心血管疾病和癌症等多种非传染性疾病中的潜在重要性和致病作用而受到广泛研究，但关于高血压的数据却很少。因此，本研究旨在通过将32名新诊断的男性高血压患者与同等数量的血压正常者进行比较，评估脂质过氧化水平、抗氧化剂水平以及血脂异常变化情况。与对照组相比，高血压患者血清脂质过氧化物水平显著升高，抗氧化酶超氧化物歧化酶以及维生素E和A水平降低。高血压患者的总胆固醇、低密度脂蛋白胆固醇、甘油三酯、体重指数较高，而高密度脂蛋白胆固醇水平较低。研究对象中高胆固醇血症、高甘油三酯血症、低高密度脂蛋白胆固醇血症和肥胖症的患病率较高。肥胖的高血压患者脂质过氧化物和脂质水平显著高于正常体重的高血压患者，而抗氧化状态无变化。我们的结果表明，高血压患者可能脂质过氧化和血脂升高，抗氧化保护作用降低，这可能促使此类患者易患心血管疾病，为纠正这种情况，除减轻体重外补充抗氧化剂可能有助于减轻负担的严重程度。
