Evans B A, Catterall R D
Br Med J. 1971 Oct 16;4(5780):146-7. doi: 10.1136/bmj.4.5780.146.
A new substituted nitroimidazole, nitrimidazine (Naxogin), is compared with the established drug, metronidazole (Flagyl), for the treatment of vaginal trichomoniasis in a randomized double-blind trial. Nitrimidazine cured 39 (68%) out of 57 patients and showed no undesirable effects other than nausea in one patient. Metronidazole cured 51 (89%) out of 57 patients and also caused nausea in one patient; this cure rate corresponds with that previously reported in other trials. In the recommended dosage nitrimidazine is inferior to metronidazole, but is sufficiently effective to be useful in cases of intolerance to metronidazole.
在一项随机双盲试验中，将一种新的取代硝基咪唑类药物硝咪唑嗪（Naxogin）与已有的药物甲硝唑（Flagyl）进行比较，以治疗阴道毛滴虫病。57例患者中，硝咪唑嗪治愈了39例（68%），除1例患者出现恶心外，未显示出其他不良影响。甲硝唑治愈了57例患者中的51例（89%），也有1例患者出现恶心；该治愈率与之前其他试验报告的治愈率相符。在推荐剂量下，硝咪唑嗪不如甲硝唑，但在对甲硝唑不耐受的情况下，其疗效足以发挥作用。
