利福平对大肠杆菌dnaC突变体中噬菌体phiX174亲本复制型DNA合成的抑制作用。
Rifampin inhibition of bacteriophage phiX174 parental replicative-form DNA synthesis in an Escherichia coli dnaC mutant.
作者信息
Dumas L B, Miller C A, Bayne M L
出版信息
J Virol. 1975 Sep;16(3):575-80. doi: 10.1128/JVI.16.3.575-580.1975.
Abstract
The Escherichia coli dnaC protein is not absolutely required in vivo for bacteriophage phiX174 parental replicative-form synthesis (Kranias and Dumas, 1974). However, when rifampin is present at a concentration that inhibits DNA-dependent RNA polymerase, phiX174 parental replicative-form synthesis is dependent on the dnaC protein activity. We conclude that E. coli DNA-dependent RNA polymerase can substitute for the dnaC protein in phiX174 parental replicative-form DNA synthesis, presumably in its initiation. The implications of this result with respect to the in vitro synthesis of the complementary strand of phiX174 DNA are discussed.
摘要
噬菌体φX174亲本复制型的合成在体内并非绝对需要大肠杆菌的dnaC蛋白（克拉尼亚斯和杜马斯，1974年）。然而，当利福平以抑制依赖DNA的RNA聚合酶的浓度存在时，φX174亲本复制型的合成依赖于dnaC蛋白的活性。我们得出结论，大肠杆菌依赖DNA的RNA聚合酶可以在φX174亲本复制型DNA合成中替代dnaC蛋白，大概是在其起始过程中。讨论了这一结果对体外合成φX174 DNA互补链的意义。
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