大肠杆菌温度敏感型dnaZ突变体中噬菌体M13和phix174双链DNA复制及单链合成的抑制作用
Inhibition of bacteriophage M13 and phix174 duplex DNA replication and single-strand synthesis in temperature-sensitive dnaZ mutants of Escherichia coli.
作者信息
Haldenwang W G, Walker J R
出版信息
J Virol. 1977 Apr;22(1):23-30. doi: 10.1128/JVI.22.1.23-30.1977.
Abstract
A functional dnaZ product, known to be essential for host DNA polymerization and for the synthesis of M13 and phiX174 parental replicative-form (RF) DNA, is required also for RF replication and single-strand synthesis by both of these phages. All three stages of M13 and phiX174DNA replication (parental RF formation, RF replication, and single-strand synthesis) are inhibited in dnazts mutants at elevated temperatures. In addition, the thermolabile step in M13 parental RF formation appears to occur after RNA priming;i.e., the synthesis of M13 RF DNA proceeded when a dnaZts mutant, infected at a nonpermissive temperature, was transferred to a permissive temperature in the presence of rifampin.
摘要
一种功能性的dnaZ产物，已知其对于宿主DNA聚合以及M13和phiX174亲本复制型（RF）DNA的合成至关重要，这两种噬菌体的RF复制和单链合成也需要它。在高温下，dnazts突变体中M13和phiX174 DNA复制的所有三个阶段（亲本RF形成、RF复制和单链合成）均受到抑制。此外，M13亲本RF形成中的热不稳定步骤似乎发生在RNA引发之后；也就是说，当在非允许温度下感染的dnaZts突变体在利福平存在的情况下转移到允许温度时，M13 RF DNA的合成仍在进行。
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