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噬菌体T7诱导的蛋白激酶对大肠杆菌依赖DNA的RNA聚合酶的体内和体外磷酸化作用。

In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.

作者信息

Zillig W, Fujiki H, Blum W, Janeković D, Schweiger M, Rahmsdorf H, Ponta H, Hirsch-Kauffmann M

出版信息

Proc Natl Acad Sci U S A. 1975 Jul;72(7):2506-10. doi: 10.1073/pnas.72.7.2506.

DOI:10.1073/pnas.72.7.2506
PMID:1101258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432797/
Abstract

After infection with bacteriophage T7 the beta' and to a lesser extent the beta subunits of E. coli DNA-dependent RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) are phosphorylated by a phage-gene-encoded protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). The phosphorylation occurs on threonine residues and appears site-specific. It is probably the molecular basis of the early transcriptional control.

摘要

用噬菌体T7感染后,大肠杆菌DNA依赖性RNA聚合酶(核苷三磷酸:RNA核苷酸基转移酶,EC 2.7.7.6)的β'亚基以及程度较轻的β亚基会被一种噬菌体基因编码的蛋白激酶(ATP:蛋白质磷酸转移酶,EC 2.7.1.37)磷酸化。磷酸化发生在苏氨酸残基上,且似乎具有位点特异性。它可能是早期转录调控的分子基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/233049629e13/pnas00050-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/ed27d1e70787/pnas00050-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/80a7b9330724/pnas00050-0041-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/0e06acec6a96/pnas00050-0041-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/bf6b0b63532c/pnas00050-0041-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/fcf8978ad4aa/pnas00050-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/29edb0dd40bd/pnas00050-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/4c3e551b3eda/pnas00050-0043-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/233049629e13/pnas00050-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/ed27d1e70787/pnas00050-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/80a7b9330724/pnas00050-0041-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/0e06acec6a96/pnas00050-0041-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/bf6b0b63532c/pnas00050-0041-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/fcf8978ad4aa/pnas00050-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/29edb0dd40bd/pnas00050-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/4c3e551b3eda/pnas00050-0043-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ca/432797/233049629e13/pnas00050-0044-a.jpg

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