Husby G, Kåss E, Spongsveen K L
Scand J Rheumatol. 1975;4(3):118-20. doi: 10.3109/03009747509165439.
Two injectable betamethasone preparations, betamethasone dipropionate/betamethasone phosphate and betamethasone acetate/betamethasone phosphate were compared in a controlled trial on 22 "matched patient pairs" with rheumatic diseases. The two preparations were injected intra-articularly in knee joints affected by active synovitis. The time until onset of action and the duration of clinically adequate anti-inflammatory effect were recorded. All injections produced clinically significant effects. The interval before recurrence of symptoms varied from 2 days to more than 3 months. The dipropionate form showed statistically significantly longer duration of action. No difference was noted in the time until onset of action. Local side effects were not observed. The double-blind method of clinical evaluation proved useful in comparing duration of action between long-acting corticosteroids.
在一项针对22对患有风湿性疾病的“匹配患者对”的对照试验中，对两种注射用倍他米松制剂——二丙酸倍他米松/磷酸倍他米松和醋酸倍他米松/磷酸倍他米松进行了比较。这两种制剂被关节腔内注射到患有活动性滑膜炎的膝关节中。记录起效时间和临床充分抗炎作用的持续时间。所有注射均产生了具有临床意义的效果。症状复发前的间隔时间从2天到3个多月不等。二丙酸酯形式显示出在统计学上显著更长的作用持续时间。在起效时间方面未观察到差异。未观察到局部副作用。临床评估的双盲法被证明有助于比较长效皮质类固醇之间的作用持续时间。
