Hartley C L, Richmond M H
Br Med J. 1975 Oct 11;4(5988):71-4. doi: 10.1136/bmj.4.5988.71.
Some antibiotics tend to select for R-factor-carrying Escherichia coli in the human gut, with complex long-term consequences. Some resistant strains disappear rapidly when treatment ends, while others persist for months in the absence of obvious antibiotic selection pressure, and the performance of individual resistant strains seems to depend more on the nature of the strain than on the plasmid carried. R plasmids are relatively rare in those E coli that colonize well in the gut and resistant bacteria therefore tend to disappear when treatment ends, but this situation could change dramatically if R plasmids became prevalent among those strains of E coli that colonize effectively.
一些抗生素往往会在人类肠道中选择携带R因子的大肠杆菌，从而产生复杂的长期后果。一些耐药菌株在治疗结束后会迅速消失，而另一些则在没有明显抗生素选择压力的情况下持续数月，而且单个耐药菌株的表现似乎更多地取决于菌株的特性，而非所携带的质粒。R质粒在那些能很好地定殖于肠道的大肠杆菌中相对较少，因此耐药菌往往在治疗结束后消失，但如果R质粒在那些能有效定殖的大肠杆菌菌株中变得普遍，这种情况可能会发生巨大变化。
