Lessey B A
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599, USA.
Baillieres Best Pract Res Clin Obstet Gynaecol. 2000 Oct;14(5):775-88. doi: 10.1053/beog.2000.0118.
Implantation is a highly co-ordinated event that involves both embryonic and endometrial participation. The endometrium expresses a sophisticated repertoire of proteins during the menstrual cycle many of which help to define a period of receptivity collectively known as the 'window of implantation'. Many of these factors, which are temporally aligned with this window, are now seen as chemical messengers that are recognized by the embryo and facilitate embryonic growth and differentiation. The use of such proteins as biomarkers has also advanced our understanding of the implantation process and may identify women with implantation failure and infertility. While the study of endometrial receptivity is still evolving, the field is growing rapidly and will probably enhance our ability to diagnose and treat couples with infertility, especially in the arena of assisted reproductive technologies (ART).
着床是一个高度协调的过程，涉及胚胎和子宫内膜的共同参与。在月经周期中，子宫内膜会表达一系列复杂的蛋白质，其中许多蛋白质有助于确定一个被统称为“着床窗口期”的接受期。许多与这个窗口期在时间上同步的这些因素，现在被视为胚胎能够识别的化学信使，有助于胚胎的生长和分化。将这些蛋白质用作生物标志物也增进了我们对着床过程的理解，并可能识别出着床失败和不孕的女性。虽然子宫内膜容受性的研究仍在不断发展，但该领域正在迅速发展，可能会提高我们诊断和治疗不孕夫妇的能力，尤其是在辅助生殖技术（ART）领域。
