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抗原对体外形成针对自身红细胞抗原的噬斑形成细胞的抑制作用。

Antigen suppression of the in vitro development of plaque-forming cells to autologous erythrocyte antigens.

作者信息

Lord E M, Dutton R W

出版信息

J Immunol. 1975 Dec;115(6):1631-5.

PMID:1102605
Abstract

Peritoneal cell cultures from NZB and C57BL/6 mice develop large numbers of PFC directed against antigens present on bromelain-treated isologous erythrocytes. The development of these autoimmune PFC can be suppressed by the addition of small numbers of BrMRBC at the start of the culture period. The possibility that the development of the plaque is prevented by the presence of antigen in vivo is discussed.

摘要

来自新西兰黑鼠（NZB）和C57BL/6小鼠的腹膜细胞培养物会产生大量针对经菠萝蛋白酶处理的同源红细胞上存在的抗原的空斑形成细胞（PFC）。在培养期开始时添加少量经溴化处理的红细胞（BrMRBC）可抑制这些自身免疫性PFC的产生。文中讨论了体内存在抗原是否会阻止空斑形成的可能性。

相似文献

1
Antigen suppression of the in vitro development of plaque-forming cells to autologous erythrocyte antigens.抗原对体外形成针对自身红细胞抗原的噬斑形成细胞的抑制作用。
J Immunol. 1975 Dec;115(6):1631-5.
2
The in vitro suppression of spontaneous erythrocyte autoimmune responses with lymphocytes activated with concanavalin A.用伴刀豆球蛋白A激活的淋巴细胞对自发性红细胞自身免疫反应的体外抑制作用。
J Immunol. 1979 Jan;122(1):265-9.
3
The properties of plaque-forming cells from autoimmune and normal strains of mice with specificity for autologous erythrocyte antigens.
J Immunol. 1975 Nov;115(5):1199-1205.
4
Characteristics of peritoneal lymphocytes from New Zealand Black and normal mice autoreactive for mouse erythrocytes.对小鼠红细胞具有自身反应性的新西兰黑鼠和正常小鼠腹膜淋巴细胞的特征
J Clin Lab Immunol. 1979 Feb;1(4):355-60.
5
Lipopolysaccharide-induced autoantibody response. II. Age-related change in plaque-forming cell response to bromelain-treated syngeneic erythrocytes.脂多糖诱导的自身抗体反应。II. 对菠萝蛋白酶处理的同基因红细胞的空斑形成细胞反应的年龄相关变化。
Int Arch Allergy Appl Immunol. 1981;66(2):161-72.
6
Spontaneous development of plaque-forming cells against sheep erythrocytes by mouse peritoneal cells in culture.培养的小鼠腹腔细胞自发产生针对绵羊红细胞的噬斑形成细胞。
Ann Immunol (Paris). 1975 Feb-Mar;126(2):231-8.
7
Immunological defects in SJL mice.SJL小鼠的免疫缺陷
Immunology. 1986 Nov;59(3):445-50.
8
The effect of antilymphocytic antibody on the humoral immune response in different strains of mice. II. The response to sheep erythrocytes.抗淋巴细胞抗体对不同品系小鼠体液免疫反应的影响。II. 对绵羊红细胞的反应。
Immunology. 1973 Mar;24(3):455-65.
9
Reconstitution of the antibody response in vitro of T cell-deprived spleen cells by supernatants from spleen cell cultures.用脾细胞培养上清液在体外重建T细胞缺失的脾细胞的抗体应答。
J Immunol. 1972 Dec;109(6):1379-85.
10
Regulatory mechanism of autoantibody production in mice to bromelin-treated isologous red blood cells.小鼠对菠萝蛋白酶处理的同源红细胞产生自身抗体的调节机制。
Immunology. 1979 Feb;36(2):257-64.

引用本文的文献

1
Ontogeny of the autoimmune reaction in normal mice to antigens in erythrocytes and gut.正常小鼠对红细胞和肠道中抗原的自身免疫反应的个体发生。
Clin Exp Immunol. 1981 Apr;44(1):38-48.
2
T cells or their products are required for the differentiation of precursor B cells into antibody-secreting cells specific for a supposed T-independent self-antigen.前体B细胞分化为针对假定的非T细胞依赖性自身抗原的抗体分泌细胞需要T细胞或其产物。
Immunology. 1987 Jun;61(2):137-42.
3
In vitro investigation of autoantibody-secreting peritoneal cells and their regulation.
分泌自身抗体的腹膜细胞及其调控的体外研究。
Immunology. 1979 Oct;38(2):355-65.