酿酒酵母减数分裂重组热点和冷点的全基因组图谱。
Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.
作者信息
Gerton J L, DeRisi J, Shroff R, Lichten M, Brown P O, Petes T D
机构信息
Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11383-90. doi: 10.1073/pnas.97.21.11383.
Abstract
In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Hotspots were nonrandomly associated with regions of high G + C base composition and certain transcriptional profiles. Coldspots were nonrandomly associated with the centromeres and telomeres.
摘要
在酿酒酵母中，减数分裂重组由双链DNA断裂（DSB）引发。减数分裂DSB在某些基因组区域（热点）以相对较高的频率发生，而在其他区域（冷点）则以相对较低的频率发生。我们使用DNA微阵列来估计所有6200个酵母基因附近减数分裂DSB水平的变化。热点与高G + C碱基组成区域和某些转录谱非随机相关。冷点与着丝粒和端粒非随机相关。
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