Matsui A, Ishihara H, Suzuki A, Hashiba E, Fukushi T, Matsuki A
Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki-Shi, Japan.
Intensive Care Med. 2000 Aug;26(8):1131-8. doi: 10.1007/s001340051328.
We have recently reported that the initial distribution volume of glucose (IDVG) reliably measures the central extracellular fluid (ECF) volume in the presence of fluid gain or loss. However, it is not clear if IDVG consistently reflects central-ECF volume when redistribution of fluid occurs in the absence of fluid gain or loss. This study was designed to investigate changes in fluid volumes during phentolamine infusion in dogs.
Prospective animal study.
Institutional animal research laboratory.
Fourteen anesthetized and ventilated mongrel dogs.
Anesthetized animals were mechanically ventilated and received infusions of normal saline (n = 7) or phentolamine (10 microg kg min) (n = 7). Plasma volume was estimated using the indocyanine green (ICG) dilution method (PV-ICG) and IDVG was calculated using a one-compartment model by simultaneous administration of ICG 0.5 mg/kg and glucose 100 mg/kg before, during, and after infusion of either drug.
PV-ICG during infusion was not different between groups. However, IDVG significantly decreased (P < 0.05) following phentolamine infusion when compared with normal saline infusion.
Our results suggest that IDVG rather than PV-ICG consistently measures central extracellular fluid volume, even when redistribution of fluid occurs.
我们最近报道，在存在液体摄入或丢失的情况下，葡萄糖初始分布容积（IDVG）能够可靠地测量中央细胞外液（ECF）容积。然而，在无液体摄入或丢失但发生液体重新分布时，IDVG是否始终反映中央ECF容积尚不清楚。本研究旨在调查酚妥拉明输注期间犬类液体容积的变化。
前瞻性动物研究。
机构动物研究实验室。
14只麻醉并通气的杂种犬。
对麻醉动物进行机械通气，并输注生理盐水（n = 7）或酚妥拉明（10微克/千克/分钟）（n = 7）。采用吲哚菁绿（ICG）稀释法估算血浆容积（PV-ICG），在输注任何一种药物之前、期间和之后，通过同时给予0.5毫克/千克ICG和100毫克/千克葡萄糖，使用单室模型计算IDVG。
输注期间两组的PV-ICG无差异。然而，与生理盐水输注相比，酚妥拉明输注后IDVG显著降低（P < 0.05）。
我们的结果表明，即使发生液体重新分布，IDVG而非PV-ICG始终能够测量中央细胞外液容积。
