Koh H, Ishihara H, Miyahara A, Takahashi S, Matsuki A
Department of Anesthesiology, University of Hirosaki, School of Medicine, Aomori-Ken, Japan.
Can J Anaesth. 1995 Feb;42(2):163-7. doi: 10.1007/BF03028271.
To test the hypothesis that the initial distribution volume of glucose (IDVG) reflects plasma volume, the relationship between the IDVG and indocyanine green (ICG) assessments of plasma volume (Vd-ICG) were evaluated simultaneously both before and after induced haemorrhage (30 ml.kg-1) in eight mongrel dogs. The IDVG and the Vd-ICG were calculated with a one-compartment model from repeated measurements of plasma glucose three to seven minutes, and of plasma ICG three to nine minutes after simultaneous infusions of both glucose 100 mg.kg-1 and ICG 0.5 mg.kg-1. The IDVG calculated with a one-compartment model (IDVG-OCM) was also compared with a two-compartment model within 15 min (IDVG-TCM) on nine occasions among a total of 12 determinations. Using Bland and Altman analysis to compare the two analytical models, the IDVG-OCM tends to overestimate the IDVG-TCM by an average of 0.04 L. Although the IDVG-OCM was two to three times larger than the Vd-ICG at each corresponding point, a correlation was obtained between the IDVG-OCM and the Vd-ICG before and after induced haemorrhage (r = 0.85, n = 16, P < 0.001). We conclude that the IDVG reflects plasma volume in normal and hypovolaemic dogs, although the IDVG cannot be used directly to estimate plasma volume.
为验证葡萄糖初始分布容积（IDVG）反映血浆容积这一假说，在8只杂种犬诱导出血（30 ml·kg⁻¹）前后，同时评估IDVG与血浆容积的吲哚菁绿（ICG）评估值（Vd-ICG）之间的关系。在同时输注100 mg·kg⁻¹葡萄糖和0.5 mg·kg⁻¹ICG后，分别于3至7分钟重复测量血浆葡萄糖、3至9分钟重复测量血浆ICG，并用单室模型计算IDVG和Vd-ICG。在总共12次测定中的9次，还在15分钟内将单室模型计算的IDVG（IDVG-OCM）与双室模型计算的IDVG（IDVG-TCM）进行比较。采用Bland和Altman分析比较这两种分析模型，IDVG-OCM往往比IDVG-TCM平均高估0.04 L。尽管在每个对应点IDVG-OCM比Vd-ICG大两到三倍，但在诱导出血前后，IDVG-OCM与Vd-ICG之间仍存在相关性（r = 0.85，n = 16，P < 0.001）。我们得出结论，在正常和低血容量犬中，IDVG反映血浆容积，尽管IDVG不能直接用于估计血浆容积。
