PMS-601，一种新型血小板活化因子受体拮抗剂，可抑制人类免疫缺陷病毒复制并增强巨噬细胞中齐多夫定的活性。
PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages.
作者信息
Martin M, Serradji N, Dereuddre-Bosquet N, Le Pavec G, Fichet G, Lamouri A, Heymans F, Godfroid J J, Clayette P, Dormont D
机构信息
CEA, Service de Neurovirologie, DSV/DRM, CRSSA, EPHE, Institut Paris-Sud sur les Cytokines, Fontenay aux Roses, France.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3150-4. doi: 10.1128/AAC.44.11.3150-3154.2000.
Abstract
We assessed the anti-human immunodeficiency virus (anti-HIV) activity in vitro of new platelet-activating factor (PAF) receptor antagonists, as PAF and viral replication are thought to be involved in HIV neuropathogenesis. We found that PMS-601 inhibited proinflammatory cytokine synthesis and HIV replication in macrophages and potentiated the antiretroviral activity of zidovudine. These results suggest that PMS-601 is of potential value as an adjuvant treatment for HIV infection.
摘要
我们评估了新型血小板活化因子（PAF）受体拮抗剂的体外抗人类免疫缺陷病毒（抗HIV）活性，因为PAF和病毒复制被认为与HIV神经发病机制有关。我们发现PMS - 601可抑制巨噬细胞中促炎细胞因子的合成和HIV复制，并增强齐多夫定的抗逆转录病毒活性。这些结果表明，PMS - 601作为HIV感染的辅助治疗具有潜在价值。
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