从流感嗜血杆菌中分离出的一种可转移的卡那霉素抗性质粒。
A transferable kanamycin resistance plasmid isolated from Haemophilus influenzae.
作者信息
Van A D, Goldstein F, Acar J F, Bouanchaud D H
出版信息
Ann Microbiol (Paris). 1975 Apr;126(3):397-9.
PMID:1103677
Abstract
Kanamycin resistance was transferred by conjugation from a Haemophilus influenzae strain into Escherichia coli K12, and between E. coli K12 strains in subsequent transfers. Covalently closed molecules of DNA were isolated by sedimentation analysis of the DNA of the resistant E. coli K12 strains. These facts support the hypothesis that kanamycin resistance is mediated by a transferable plasmid in this strain of H. influenzae.
摘要
卡那霉素抗性通过接合作用从一株流感嗜血杆菌转移到大肠杆菌K12中，并在随后的转移中在大肠杆菌K12菌株之间转移。通过对耐药大肠杆菌K12菌株的DNA进行沉降分析，分离出了共价闭合的DNA分子。这些事实支持了这样一种假说，即在这株流感嗜血杆菌中，卡那霉素抗性是由一种可转移的质粒介导的。
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