从淋病奈瑟菌中分离出的两种β-内酰胺酶编码质粒的分子特征
Molecular characterization of two beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae.
作者信息
Roberts M, Elwell L P, Falkow S
出版信息
J Bacteriol. 1977 Aug;131(2):557-63. doi: 10.1128/jb.131.2.557-563.1977.
Abstract
The molecular nature of two distinct gonococcal R plasmids, 4.4 X 10(6) and 3.2 X 10(6) daltons, encoding beta-lactamase activity were examined. Both plasmids contained about 40% of the transposable ampicillin resistance sequence Tn2. Deoxyribonucleic acid-deoxyribonucleic acid polynucleotide sequence studies have shown that the two gonococcal plasmids share about 70% of their sequences and are closely related to RSF0885, a 4.1 X 10(6)-dalton plasmid found in a beta-lactamase-producing strain of Haemophilus influenzae. All three of these R plasmids possess a guanine-plus-cytosine content of 0.40 to 0.41 mol fraction and are present as multicopy gene pools in their bacterial hosts.
摘要
对编码β-内酰胺酶活性的两种不同淋球菌R质粒（分子量分别为4.4×10⁶和3.2×10⁶道尔顿）的分子特性进行了研究。两种质粒均含有约40%的转座型氨苄青霉素抗性序列Tn2。脱氧核糖核酸-脱氧核糖核酸多核苷酸序列研究表明，这两种淋球菌质粒约70%的序列相同，并且与RSF0885密切相关，RSF0885是在一株产β-内酰胺酶的流感嗜血杆菌中发现的分子量为4.1×10⁶道尔顿的质粒。所有这三种R质粒的鸟嘌呤加胞嘧啶含量为0.40至0.41摩尔分数，并且以多拷贝基因库的形式存在于其细菌宿主中。
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