Fanning T G, Reid A H, Taubenberger J K
Division of Molecular Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306-6000, USA.
Virology. 2000 Oct 25;276(2):417-23. doi: 10.1006/viro.2000.0578.
Phylogenetically informative amino acid positions (PIPs) were identified in influenza A neuraminidases of subtypes N1 and N2. Neuraminidase evolves in a lineage-specific way as the virus adapts to a new host or changes to evade the host's immune system. Thus, many PIPs undoubtedly identify positions involved in virus-host interactions. Phylogenetically important regions (PIRs) are defined as several PIPs near one another. There are 15 PIRs on N1 and 12 on N2, seven of which are shared between the two subtypes. Many PIRs are coincident with antigenic or glycosylation sites. Other PIRs may represent additional antigenic sites or may be involved in other aspects of virus-host biology.
在甲型流感病毒N1和N2亚型的神经氨酸酶中鉴定出了系统发育信息丰富的氨基酸位点（PIPs）。随着病毒适应新宿主或发生变化以逃避宿主免疫系统，神经氨酸酶以谱系特异性方式进化。因此，许多PIPs无疑识别出参与病毒-宿主相互作用的位点。系统发育重要区域（PIRs）被定义为彼此相邻的几个PIPs。N1上有15个PIRs，N2上有12个，其中7个在两种亚型之间共享。许多PIRs与抗原或糖基化位点重合。其他PIRs可能代表额外的抗原位点，或者可能参与病毒-宿主生物学的其他方面。
