Raman Rahul, Tharakaraman Kannan, Sasisekharan V, Sasisekharan Ram
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States.
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States.
Curr Opin Struct Biol. 2016 Oct;40:153-162. doi: 10.1016/j.sbi.2016.10.003. Epub 2016 Oct 25.
The surfaces of host cells and viruses are decorated by complex glycans, which play multifaceted roles in the dynamic interplay between the virus and the host including viral entry into host cell, modulation of proteolytic cleavage of viral proteins, recognition and neutralization of virus by host immune system. These roles are mediated by specific multivalent interactions of glycans with their cognate proteins (generally termed as glycan-binding proteins or GBPs or lectins). The advances in tools and technologies to chemically synthesize and structurally characterize glycans and glycan-GBP interactions have offered several insights into the role of glycan-GBP interactions in viral pathogenesis and have presented opportunities to target these interactions for novel antiviral therapeutic or vaccine strategies. This review covers aspects of role of host cell surface glycan receptors and viral surface glycans in viral pathogenesis and offers perspectives on how to employ various analytical tools to target glycan-GBP interactions.
宿主细胞和病毒的表面都装饰有复杂的聚糖，这些聚糖在病毒与宿主之间的动态相互作用中发挥着多方面的作用，包括病毒进入宿主细胞、调节病毒蛋白的蛋白水解切割、宿主免疫系统对病毒的识别和中和。这些作用是由聚糖与其同源蛋白（通常称为聚糖结合蛋白或GBP或凝集素）之间特定的多价相互作用介导的。化学合成和结构表征聚糖以及聚糖-GBP相互作用的工具和技术的进展，为聚糖-GBP相互作用在病毒发病机制中的作用提供了一些见解，并为针对这些相互作用开发新型抗病毒治疗或疫苗策略提供了机会。本综述涵盖了宿主细胞表面聚糖受体和病毒表面聚糖在病毒发病机制中的作用方面，并就如何利用各种分析工具靶向聚糖-GBP相互作用提供了观点。
