Yeo J H, Lee K G, Kim H C, Kim A J, Kim S Y
Department of Sericulture and Entomology, National Institute of Agriculture and Technology, Suwon, Korea.
Biol Pharm Bull. 2000 Oct;23(10):1220-3. doi: 10.1248/bpb.23.1220.
The effects of poly vinyl alcohol (PVA)/Chitosan/Fibroin (PCF)-blended sponge on wound healing in rats were investigated. We excised the skin of a rat, including the dermis, approximately 2 x 2 cm in size. The wound was covered with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12 d later showed an increase of vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroin, alone or in various combinations. Wound healing was accelerated in the order of PCF-blended sponge>Chitosan/Fibroin (CF)-blended sponge>Fibroin (F) sponge > PVA/Chitosan-blended sponge (PC) > Chitosan (C) sponge.
研究了聚乙烯醇（PVA）/壳聚糖/丝素蛋白（PCF）共混海绵对大鼠伤口愈合的影响。我们切除了大鼠约2×2 cm大小包括真皮层的皮肤。伤口用PCF共混海绵片覆盖。海绵片吸收渗出液，并获得柔韧性和柔软度。12天后伤口的组织病理学检查显示血管向内生长增加且无炎症细胞。伤口周围皮肤的再生比对照组更快。我们还测试了单独使用或各种组合使用的PVA、壳聚糖和丝素蛋白的伤口愈合效果。伤口愈合加速的顺序为：PCF共混海绵>壳聚糖/丝素蛋白（CF）共混海绵>丝素蛋白（F）海绵>PVA/壳聚糖共混海绵（PC）>壳聚糖（C）海绵。
