毒力梅毒螺旋体利用的碳源。
Carbon sources utilized by virulent Treponema pallidum.
作者信息
Nichols J C, Baseman J B
出版信息
Infect Immun. 1975 Nov;12(5):1044-50. doi: 10.1128/iai.12.5.1044-1050.1975.
Abstract
Carbon sources utilized by virulent Treponema pallidum organisms extracted from infected rabbit tissue have been investigated. Utilization of 14C-labeled compounds by T. pallidum was monitored by degradation of these compounds to 14CO2. Experiments have consistently shown that of 22 carbon sources examined, [14C]glucose and [14C]pyruvate are selectively degraded to 14CO2 under the experimental conditions employed. When [1-14C]pyruvate, [2-14C]pyruvate, and [3-14C]pyruvate are tested, virulent T. pallidum preferentially degrade and release the carboxyl group as 14CO2. End product analyses indicate that CO2 and acetate are the major products of pyruvate degradation by T. pallidum.
摘要
对从感染兔组织中提取的致病性梅毒螺旋体所利用的碳源进行了研究。通过将这些化合物降解为(^{14}CO_2)来监测梅毒螺旋体对(^{14}C)标记化合物的利用情况。实验一直表明，在所检测的22种碳源中，在所用实验条件下，([^{14}C])葡萄糖和([^{14}C])丙酮酸会选择性地降解为(^{14}CO_2)。当测试([1-^{14}C])丙酮酸、([2-^{14}C])丙酮酸和([3-^{14}C])丙酮酸时，致病性梅毒螺旋体会优先降解并将羧基作为(^{14}CO_2)释放出来。终产物分析表明，(CO_2)和乙酸盐是梅毒螺旋体降解丙酮酸的主要产物。
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